In this article, we prove Grothendieck’s Vanishing and Non-vanishing Theorems of local cohomology objects in the non-commutative algebraic geometry framework of Artin and Zhang. Let k be a field of characteristic zero and \({\mathscr {S}}_{k}\) be a strongly locally noetherian k-linear Grothendieck category. For a commutative noetherian k-algebra R, let \({\mathscr {S}}_R\) denote the category of R-objects in \({\mathscr {S}}_k\) obtained through a non-commutative base change by R of the abelian category \({\mathscr {S}}_{k}\) . First, we establish Grothendieck’s Vanishing Theorem for any object \({\mathscr {M}}\) in \({\mathscr {S}}_{R}\) . Further, if R is local and \({\mathscr {S}}_{k}\) is Hom-finite, we prove Non-vanishing Theorem for any finitely generated flat object \({\mathscr {M}}\) in \({\mathscr {S}}_R\) .
