For an imaginary biquadratic number field \(K = \mathbb Q(\sqrt{-q},\sqrt d)\) , where \(q>3\) is a prime congruent to \(3 \pmod 8\) , and \(d\) is an odd square-free integer which is not equal to q, let \(K_\infty\) be the cyclotomic \(\mathbb Z_2\) -extension of \(K\) . For any integer \(n \geq 0\) , we denote by \(K_n\) the nth layer of \(K_\infty/K\) . We investigate the rank of the 2-class group of \(K_n\) , then we draw the list of all number fields K such that the Galois group of the maximal unramified pro-2-extension over their cyclotomic \(\mathbb Z_2\) -extension is metacyclic pro-2 group.