We characterize algebraic integers which are differences of twoPisot numbers. Each such number \(\alpha\) must be real and its conjugates over \(\mathbb{Q}\) mustall lie in the union of the disc \(|z|<2\) and the strip \(|\Im(z)|<1\) . In particular, weprove that every real algebraic integer \(\alpha\) whose conjugates over \(\mathbb{Q}\) , except possiblyfor \(\alpha\) itself, all lie in the disc \(|z|<2\) can always be written as a difference oftwo Pisot numbers. We also show that a real quadratic algebraic integer \(\alpha\) withconjugate \(\alpha'\) over \(\mathbb{Q}\) is always expressible as a difference of two Pisot numbers exceptfor the cases \(\alpha<\alpha'<-2\) or \(2<\alpha'<\alpha\) when \(\alpha\) cannot be expressed in thatform. A similar complete characterization of all algebraic integers \(\alpha\) expressibleas a difference of two Pisot numbers in terms of the location of their conjugatesis given in the case when the degree \(d\) of \(\alpha\) is a prime number.