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<p>Mobile health (mHealth) interventions offer scalable support for adherence and self-management, yet their effects on health-related quality of life (HRQoL) among people living with HIV (PLWH) and comorbid hypertension remain unclear. We evaluated HRQoL outcomes using data from the MOPHADHIV trial, a 12-month short message service (SMS)-based randomized controlled trial conducted at four community health centres in Cape Town, South Africa. HRQoL was measured using the EuroQol 5-Dimension 5-Level (EQ-5D-5L) utility index (Ugandan value set) and the EuroQol Visual Analogue Scale (VAS) at baseline and 12&#xa0;months. Between-group differences were assessed using two-sample t-tests and analysis of covariance (ANCOVA) models adjusting for baseline HRQoL and covariates. A total of 582 participants (279 control; 303 intervention) with complete HRQoL data at baseline and 12&#xa0;months were included in the analysis. Baseline HRQoL was high and comparable across arms. At 12&#xa0;months, EQ-5D-5L utility was slightly higher in the control arm (0.97 vs 0.95; mean difference 0.03; t = 2.66, p = 0.01), corresponding to a small effect size (Cohen’s d = 0.22). In adjusted models, intervention allocation was associated with a small reduction in EQ-5D-5L utility (β = − 0.02, p = 0.01; fully adjusted β = − 0.03, p &lt; 0.01). VAS scores improved in both groups, with no significant between-arm differences. In this cohort of PLWH with hypertension, a 12-month SMS-based intervention did not improve HRQoL and was associated with a small reduction in EQ-5D-5L utility. High baseline HRQoL and limited sensitivity of EQ-5D-5L to HIV-related psychosocial domains may partly explain these findings.</p>

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Health-Related Quality of Life in People Living with HIV andHypertension: Effects of a Short Message Service-Based Mobile HealthIntervention (MOPHADHIV Trial)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月13日

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  • Danleen James Hongoro,
  • Andre Pascal Kengne,
  • Nasheeta Peer,
  • Kim Nguyen,
  • Olufunke A. Alaba

摘要

Mobile health (mHealth) interventions offer scalable support for adherence and self-management, yet their effects on health-related quality of life (HRQoL) among people living with HIV (PLWH) and comorbid hypertension remain unclear. We evaluated HRQoL outcomes using data from the MOPHADHIV trial, a 12-month short message service (SMS)-based randomized controlled trial conducted at four community health centres in Cape Town, South Africa. HRQoL was measured using the EuroQol 5-Dimension 5-Level (EQ-5D-5L) utility index (Ugandan value set) and the EuroQol Visual Analogue Scale (VAS) at baseline and 12 months. Between-group differences were assessed using two-sample t-tests and analysis of covariance (ANCOVA) models adjusting for baseline HRQoL and covariates. A total of 582 participants (279 control; 303 intervention) with complete HRQoL data at baseline and 12 months were included in the analysis. Baseline HRQoL was high and comparable across arms. At 12 months, EQ-5D-5L utility was slightly higher in the control arm (0.97 vs 0.95; mean difference 0.03; t = 2.66, p = 0.01), corresponding to a small effect size (Cohen’s d = 0.22). In adjusted models, intervention allocation was associated with a small reduction in EQ-5D-5L utility (β = − 0.02, p = 0.01; fully adjusted β = − 0.03, p < 0.01). VAS scores improved in both groups, with no significant between-arm differences. In this cohort of PLWH with hypertension, a 12-month SMS-based intervention did not improve HRQoL and was associated with a small reduction in EQ-5D-5L utility. High baseline HRQoL and limited sensitivity of EQ-5D-5L to HIV-related psychosocial domains may partly explain these findings.