<p>The Innovative Administration of Long-Acting Injectables for HIV Treatment Enhancement at Home (INVITE-Home) study is the first to examine the implementation of home-based long-acting injectable antiretroviral therapy (LAI-ART) administered by a trained treatment buddy, such as a family member, partner, or friend. We conducted semi-structured qualitative interviews with 19 clinicians from four HIV clinics in the San Francisco Bay Area between June and December 2024 to explore perceived facilitators, barriers, and training needs related to home-based LAI-ART. Participants included physicians (<i>n</i> = 7), pharmacists (<i>n</i> = 4), nurses (<i>n</i> = 4), nurse practitioners (<i>n</i> = 2), and social workers (<i>n</i> = 2). Using an Implementation Research Logic Model to guide analysis, clinicians identified anticipated benefits of home-based administration, including reduced transportation and scheduling barriers, increased convenience and flexibility, and greater privacy. They emphasized the potential for home administration to foster patient-centered care, reduce stigma, and support treatment in familiar environments. Empowerment and autonomy were viewed as central to enhancing patient engagement and adherence, while some noted the opportunity to improve clinic efficiency by alleviating capacity constraints and freeing up provider time. Reported barriers included concerns about injection accuracy, the complexity of insurance and billing systems, communication gaps between clinical teams and patients or buddies, and the availability and reliability of treatment buddies. These findings highlight the need for comprehensive planning, structured training for treatment buddies, and sustained clinical support to address logistical and interpersonal challenges. Successful implementation will require balancing these challenges while maximizing the benefits of convenience, patient-centered care, and expanded access to LAI-ART.</p>