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<p>Pain is prevalent among people with HIV (PWH), and many PWH whoexperience pain also use substances (illicit drug and/or unhealthy alcohol use).While cocaine use and cocaine and alcohol co-use are prevalent in this population,their effects on pain in PWH are unknown. This study aims to investigate theassociation of cocaine use and co-use of cocaine and alcohol with pain interferenceamong PWH. We completed a secondary analysis of the Boston Alcohol ResearchCollaboration on HIV/AIDS (ARCH) study, a longitudinal cohort of PWH with a historyof substance use. The outcome was pain interference (Brief Pain Inventory).Exposures were recent cocaine use (Addiction Severity Index) and recent unhealthyalcohol use (Timeline Follow Back). Generalized Estimating Equation (GEE) ordinallogistic regression models were employed, adjusted for demographic factors,illicit/non-medical opioid use and cannabis use. Among 251 participants,22.3% reported unhealthy alcohol use only, 11.1% reported cocaine useonly, and 13.2% reported use of both. Cocaine use was associated with greaterpain interference (adjusted odds ratio [aOR]: 1.73, 95% confidence interval[CI]: 1.15–2.60), whether or not participants had unhealthy alcohol use(interaction term, <i>p</i> = 0.695).Participants reporting both cocaine and unhealthy alcohol use had greater paininterference than participants reporting neither (aOR: 2.27, 95%CI:1.35–3.79). Cocaine use was associated with greater pain interference as wasco-use of cocaine and unhealthy alcohol among PWH. Considering patterns of substanceuse can inform clinicians conversations with PWH who may be using substances forpain management.</p>

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Cocaine Use, Unhealthy Alcohol Use, and Pain Interference Among People with HIV

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月5日

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  • Jonah Sheinin,
  • Thomas D. Brothers,
  • Michael D. Stein,
  • Michael R. Winter,
  • Tibor P. Palfai,
  • Kara M. Magane,
  • Scarlett Bellamy,
  • Mark Asbridge,
  • Theresa W. Kim

摘要

Pain is prevalent among people with HIV (PWH), and many PWH whoexperience pain also use substances (illicit drug and/or unhealthy alcohol use).While cocaine use and cocaine and alcohol co-use are prevalent in this population,their effects on pain in PWH are unknown. This study aims to investigate theassociation of cocaine use and co-use of cocaine and alcohol with pain interferenceamong PWH. We completed a secondary analysis of the Boston Alcohol ResearchCollaboration on HIV/AIDS (ARCH) study, a longitudinal cohort of PWH with a historyof substance use. The outcome was pain interference (Brief Pain Inventory).Exposures were recent cocaine use (Addiction Severity Index) and recent unhealthyalcohol use (Timeline Follow Back). Generalized Estimating Equation (GEE) ordinallogistic regression models were employed, adjusted for demographic factors,illicit/non-medical opioid use and cannabis use. Among 251 participants,22.3% reported unhealthy alcohol use only, 11.1% reported cocaine useonly, and 13.2% reported use of both. Cocaine use was associated with greaterpain interference (adjusted odds ratio [aOR]: 1.73, 95% confidence interval[CI]: 1.15–2.60), whether or not participants had unhealthy alcohol use(interaction term, p = 0.695).Participants reporting both cocaine and unhealthy alcohol use had greater paininterference than participants reporting neither (aOR: 2.27, 95%CI:1.35–3.79). Cocaine use was associated with greater pain interference as wasco-use of cocaine and unhealthy alcohol among PWH. Considering patterns of substanceuse can inform clinicians conversations with PWH who may be using substances forpain management.