<p>An estimated 34-47% of PWH in the US report cigarette smoking, three to four times the prevalence observed in the U.S. adult population. Given the dearth of smoking cessation interventions for PWH, our study team used community based participatory feedback to design and develop the Sense2Quit App, an mHealth app linked to a smartwatch, whose sensor technology provides for collection of hand gesture movements to detect when a participant lifts their hand to smoke a cigarette. Participants receive messages through the app to encourage their quit attempts and maintenance of smoking cessation. The goal of this feasibility study was to conduct a randomized feasibility study in 60 PWH living in NYC to assess the feasibility and acceptability of the Sense2Quit App for smoking cessation. Findings from this study suggest that the intervention was highly feasible and acceptable in this population. There was high acceptability with only 1 participant withdrawing from the trial and overall app usage increasing over the course of the study. Participants wore the sensor and used the app and rated it as highly usable. The high retention rate and engagement with the app supports the overall acceptability of this approach. ClinicalTrials.gov Identifier: NCT05609032.</p>