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<p>Antiretroviral therapy (ART) adherence is crucial for HIV viral suppression. Tenofovir diphosphate (TFV-DP) concentrations in dried blood spots (DBS) offer a potential tool for monitoring and supporting adherence. We assessed acceptability and preferences of fingerstick-based DBS collection and drug-level feedback among 224 people living with HIV (PLWH) in South Africa. DBS monitoring was highly acceptable (99%) and viewed as helpful (96%). Participants indicated willingness for clinic staff-administered collection (79.5%) and less willingness for community health workers (26.1%) or pharmacists (37.0%). Participants favored receiving results in clinic (52%). These findings demonstrate high acceptability and strong preferences among participants for DBS-based collection procedures.</p>

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Brief Report: Preferences and Acceptability in Methods of Tenofovir Diphosphate in Dried Blood Spots Collection and Feedback in a Cohort of PLWH in Cape Town South Africa

  • 期刊论文

  • 发表日期：

    2025年1月30日

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  • Paul A. D’Avanzo,
  • Christopher M. Ferraris,
  • Melissa Pence-Moore,
  • Lauren Jennings,
  • Reuben N. Robbins,
  • Catherine Orrell,
  • Robert H. Remien

摘要

Antiretroviral therapy (ART) adherence is crucial for HIV viral suppression. Tenofovir diphosphate (TFV-DP) concentrations in dried blood spots (DBS) offer a potential tool for monitoring and supporting adherence. We assessed acceptability and preferences of fingerstick-based DBS collection and drug-level feedback among 224 people living with HIV (PLWH) in South Africa. DBS monitoring was highly acceptable (99%) and viewed as helpful (96%). Participants indicated willingness for clinic staff-administered collection (79.5%) and less willingness for community health workers (26.1%) or pharmacists (37.0%). Participants favored receiving results in clinic (52%). These findings demonstrate high acceptability and strong preferences among participants for DBS-based collection procedures.