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COVID-19 Vaccine Acceptance and Hesitancy among People Living with HIV: Review and Meta-Analysis

  • Marcos Pereira,
  • Italo Ricardo Santos Aleluia,
  • Caroline Tianeze de Castro,
  • Tarcio de Almeida Oliveira,
  • Mila Silva Cunha,
  • Laio Magno,
  • Inês Dourado,
  • Florisneide Barreto,
  • Marcio Natividade,
  • Seth Christopher Yaw Appiah,
  • Erick Abade,
  • Enny S. Paixao,
  • Maria Lidiany Tributino de Souza

摘要

This study aims to estimate the COVID-19 vaccine acceptance and hesitancy among people living with HIV (PLWHA). A search for observational studies was conducted in five databases and preprinted literature. Summary estimates were pooled using a random effects model and meta-regression. Of 150 identified studies, 31 were eligible (18,550 PLWHA). The weighted prevalence of COVID-19 vaccine hesitancy overall was 29.07% among PLWHA (95%CI = 24.33–34.32; I² = 98%,) and that of vaccine acceptance was 68.66% (95%CI = 62.25–74.43; I² = 98%). Higher hesitancy prevalence was identified in low/lower-middle income countries (35.05; 95% CI = 19.38–54.78). The heterogeneity was explained by the risk of bias, region, and year of data collection. The findings conclude that the COVID-19 vaccine hesitancy rate remains high, especially in low-income countries. Evidence-informed interventions aimed at increasing COVID-19 vaccine acceptance at the national and individual levels ought to be designed to increase COVID-19 vaccine acceptance among PLWHA.