<p>Evaluating the damage tolerance of CFRP structures with wrinkle defects under impact loading is crucial for safe service of the composite structures. In this study, the impact tests and compression tests after impact on CFRP specimens with two different wrinkle sizes under three different impact energies are conducted. The damage tolerance of CFRP specimens under varying impact energies and wrinkle defects is evaluated through impact response and compression response. The results indicate that, corresponding to the theory, the maximum contact force exhibits significant stepwise increase with the increase of impact energy no matter what kind of wrinkle size. However, it should be emphasized that, under the same impact energy, the effect of the wrinkle size on the impact performance is not significant with the variation rate of the maximum contact force less than 10%. In terms of impact damage, the specimens subjected to higher impact energy exhibit severe delamination, and the effect of wrinkle size on impact delamination under the same impact energy is more significant at higher impact energy. As for the compression response, due to the effect of the impact damage and wrinkle fibers, the impact energy and wrinkle size both have significant effect on the residual compressive strength. Moreover, the wrinkle fibers play a dominant role in the compression failure mode of the specimen, while the impact damage caused by impact energy influences the extent of the compression failure of the specimen.</p>