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<p>Population genetics relies heavily on homozygosity statistics. Over the past two decades, however, as the number and applications of homozygosity-based statistics has increased, there has been a crisis of confidence. Homozygosity statistics are mathematically constrained by other population genetics statistics, such as maximum allele frequency, creating problems for interpretation and portability. Mathematical investigations into these constraints have been criticized for being irrelevant to biology. Noah Rosenberg’s new book <i>Mathematical Properties of Population-Genetic Statistics</i> is his response to these concerns. While accepting many of the criticisms, Rosenberg shows that careful attention to purely mathematical constraints on homozygosity can be leveraged to design new statistics to achieve new goals.</p>

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A Crisis of Population Genetics Statistics

  • 期刊论文

  • 发表日期：

    2026年2月12日

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  • Matthew J. Maxwell

摘要

Population genetics relies heavily on homozygosity statistics. Over the past two decades, however, as the number and applications of homozygosity-based statistics has increased, there has been a crisis of confidence. Homozygosity statistics are mathematically constrained by other population genetics statistics, such as maximum allele frequency, creating problems for interpretation and portability. Mathematical investigations into these constraints have been criticized for being irrelevant to biology. Noah Rosenberg’s new book Mathematical Properties of Population-Genetic Statistics is his response to these concerns. While accepting many of the criticisms, Rosenberg shows that careful attention to purely mathematical constraints on homozygosity can be leveraged to design new statistics to achieve new goals.