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<p>Assessment of the contractile function of the heart typically requires resource demanding techniques, such as invasive left ventricular catheterisation or intermittent medical imaging, and is therefore not readily available for continuous clinical or remote monitoring. Measurement of heart wall motion by use of an epicardially attached three-axis accelerometer has emerged as a promising tool for monitoring cardiac function; however, previous methods have often underutilised the spatial and temporal information contained in the measured signals, potentially limiting its clinical reliability. This work reconstructs the position of an epicardial accelerometer in 3D space in order to enable extraction of indices of cardiac function in a Lagrangian frame of reference. The standard deviation of Lagrangian acceleration throughout a heartbeat, <InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="10439_2025_3828_Article_IEq1.gif" Format="GIF" Height="12" Rendition="HTML" Resolution="72" Type="Linedraw" Width="31" /> </InlineMediaObject> <EquationSource Format="TEX">\(\sigma _{Acc}\)</EquationSource> <EquationSource Format="MATHML"><math> <msub> <mi>σ</mi> <mrow> <mi mathvariant="italic">Acc</mi> </mrow> </msub> </math></EquationSource> </InlineEquation>, is introduced as a novel surrogate indicator of contractility as changes in <InlineEquation ID="IEq2"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="10439_2025_3828_Article_IEq1.gif" Format="GIF" Height="12" Rendition="HTML" Resolution="72" Type="Linedraw" Width="31" /> </InlineMediaObject> <EquationSource Format="TEX">\(\sigma _{Acc}\)</EquationSource> <EquationSource Format="MATHML"><math> <msub> <mi>σ</mi> <mrow> <mi mathvariant="italic">Acc</mi> </mrow> </msub> </math></EquationSource> </InlineEquation> correlated strongly with changes in the maximum rate of change in left ventricular pressure in animal data (n=29) spanning a variety of haemodynamic conditions. The reported findings of this proof-of-principle study may represent a first step towards long-term monitoring of contractile function and expands on the current repertoire of use for epicardially attached accelerometers as versatile, continuous, and autonomous monitoring devices.</p>

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Continuous and Autonomous Monitoring of Changes in Left Ventricular dP/dtmax Using an Epicardial Accelerometer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月18日

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  • Vetle Christoffer Frostelid,
  • Ali Wajdan,
  • Manuel Villegas-Martinez,
  • Lars-Egil R. Hammersboen,
  • Andreas Espinoza,
  • Ole-Johannes H. N. Grymyr,
  • Per Steinar Halvorsen,
  • Ole Jakob Elle,
  • Espen W. Remme

摘要

Assessment of the contractile function of the heart typically requires resource demanding techniques, such as invasive left ventricular catheterisation or intermittent medical imaging, and is therefore not readily available for continuous clinical or remote monitoring. Measurement of heart wall motion by use of an epicardially attached three-axis accelerometer has emerged as a promising tool for monitoring cardiac function; however, previous methods have often underutilised the spatial and temporal information contained in the measured signals, potentially limiting its clinical reliability. This work reconstructs the position of an epicardial accelerometer in 3D space in order to enable extraction of indices of cardiac function in a Lagrangian frame of reference. The standard deviation of Lagrangian acceleration throughout a heartbeat, \(\sigma _{Acc}\) σ Acc , is introduced as a novel surrogate indicator of contractility as changes in \(\sigma _{Acc}\) σ Acc correlated strongly with changes in the maximum rate of change in left ventricular pressure in animal data (n=29) spanning a variety of haemodynamic conditions. The reported findings of this proof-of-principle study may represent a first step towards long-term monitoring of contractile function and expands on the current repertoire of use for epicardially attached accelerometers as versatile, continuous, and autonomous monitoring devices.