<p>Cerebrovascular diseases, particularly intracranial aneurysms, pose significant mortality risks globally. Hemodynamics plays a crucial role in aneurysm initiation, growth, and rupture. In this paper, the pulsating blood flow and the effects of fluid-structure interaction on a real internal carotid artery were investigated using the arbitrary Lagrangian-Eulerian approach, with considerations of non-Newtonian blood flow properties, the arterial wall as a linear elastic material, and transient simulations. Eight different physiological pressure conditions were analyzed to understand the impact of blood pressure variations on aneurysm hemodynamics. It is indicated that local geometric changes in the artery affect hemodynamic parameters; high wall pressure gradient, high wall shear stress, and high time-averaged wall shear stress (TAWSS) occur in areas with complex geometry, regardless of blood pressure. These parameters are crucial for assessing aneurysm rupture risk. It’s predicted that areas with high oscillatory shear index and low TAWSS may be at higher risk for aneurysm rupture. Moreover, increased blood pressure will lead to changes in aneurysm shape and increased wall stress. This study underscores the importance of integrating hemodynamic and structural mechanics analyses for accurate aneurysm rupture risk assessment. While hemodynamic parameters provide critical insights into endothelial cell interactions and aneurysm growth, mechanical responses to blood pressure variations highlight the potential for aneurysm expansion and rupture. The findings emphasize that clinical decision-making should consider both hemodynamic factors and arterial wall mechanics, offering a comprehensive framework for understanding aneurysm pathophysiology and guiding treatment strategies.</p>