<p>This study investigates the enhancement of blood flow in stenotic arteries using gold (Au) and silver (Ag) nanoparticles, a topic of significant importance due to its potential applications in targeted drug delivery and the treatment of cardiovascular diseases. A mathematical model of a narrowed arterial segment is developed to analyse nanoparticle transport under restricted flow conditions. The governing partial differential equations are transformed into dimensionless ordinary differential equations using suitable similarity transformations and are solved numerically using the Keller box method in MATLAB. The results demonstrate that the inclusion of Au and Ag nanoparticles significantly alters the hydrodynamic and thermal behaviour of blood, leading to improved flow characteristics and reduced adverse effects of arterial narrowing. It is observed that increasing the size of gold nanoparticles decreases both blood velocity and temperature. Furthermore, thermal radiation and heat source/sink parameters are found to strongly influence the temperature distribution, with higher radiation and Biot numbers intensifying thermal variations. These findings highlight the effectiveness of nanoparticle-assisted approaches in regulating blood flow and improving therapeutic outcomes in stenotic arterial systems.</p>