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<p>Catheter Associated Urinary Tract Infections (CAUTIs) pose a significant challenge in clinical settings due to bacterial colonization and biofilm formation on indwelling catheters. Conventional models, including in vitro and ex vivo systems with artificial urine flow, have historically facilitated the exploration of catheter efficacy and antimicrobial interventions. Nevertheless, these models often exhibit shortcomings, including substantial resource requirements, ethical dilemmas, and limited physiological mimicking with correct relevance. Recent innovations in microfluidic technology, exemplified by organ-on-a-chip systems, present a promising alternative by accurately simulating the human urinary tract milieu under dynamic conditions. This article presents a comparative examination of traditional urinary tract models and microfluidic devices, elucidating their respective capabilities, constraints, and applications in the development of antimicrobial drugs using urinary tract infection experimental models. Through this comparison, the manuscript emphasizes the enhanced precision, scalability, and real-time analytical capabilities of microfluidic platforms while also recognizing the fundamental contributions of conventional models. The findings aim to inform future inquiries and advances in catheter technology, advocating a hybrid methodology that leverages the strengths of both systems to improve infection management and antimicrobial drug development research.</p>

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Advancing experimental models of catheters associated urinary tract infection research: from traditional to microfluidic platforms

  • 期刊论文

  • 发表日期：

    2026年7月8日

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  • Antara Tandi,
  • Shristi Panigrahi,
  • Shraavani Konatam,
  • Dijendra Nath Roy

摘要

Catheter Associated Urinary Tract Infections (CAUTIs) pose a significant challenge in clinical settings due to bacterial colonization and biofilm formation on indwelling catheters. Conventional models, including in vitro and ex vivo systems with artificial urine flow, have historically facilitated the exploration of catheter efficacy and antimicrobial interventions. Nevertheless, these models often exhibit shortcomings, including substantial resource requirements, ethical dilemmas, and limited physiological mimicking with correct relevance. Recent innovations in microfluidic technology, exemplified by organ-on-a-chip systems, present a promising alternative by accurately simulating the human urinary tract milieu under dynamic conditions. This article presents a comparative examination of traditional urinary tract models and microfluidic devices, elucidating their respective capabilities, constraints, and applications in the development of antimicrobial drugs using urinary tract infection experimental models. Through this comparison, the manuscript emphasizes the enhanced precision, scalability, and real-time analytical capabilities of microfluidic platforms while also recognizing the fundamental contributions of conventional models. The findings aim to inform future inquiries and advances in catheter technology, advocating a hybrid methodology that leverages the strengths of both systems to improve infection management and antimicrobial drug development research.