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<p>A three-dimensional electrochemical origami-paper integrated cell chamber (3DP EO-PICC) that detects methamphetamine, an illicit drug, at a minimum concentration of 0.01&#xa0;µg/mL is presented in this study. The sensor was made from an ecologically friendly polylactic acid (PLA) filament with a single foldable origami flap and a central reaction chamber for loading samples onto the paper printed electrode. The electrode acts as a reaction chamber where analyte interact with the pre-deposited zinc oxide &amp; graphene oxide nanocomposite (ZnO-GO NCs), which is manufactured using a chemical reduction technique. Cyclic voltammetry (CV), linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS) were used for the detection of methamphetamine (Meth), proving the sensor’s excellent sensitivity. Integrating 3D printing with nano-biosensing devices allow accurate spatial positioning of nanoscale components, improves analyte interaction via greater surface area, and enables adjustable sensor designs. This technique facilitates the inclusion of complicated structures into sensor design while also enabling scalable, cost-effective manufacture, opening the way for creative and practical biosensing platforms.</p> Graphical abstract <p></p>

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3D printed electrochemical origami-paper integrated cell chamber (EO-PICC) engineered with hierarchical nanocomposites for achieving unparalleled sensitivity in methamphetamine drug detection

  • 期刊论文

  • 发表日期：

    2026年4月3日

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  • Nigar Anzar,
  • Yashda Singh,
  • Shariq Suleman,
  • Jagriti Narang

摘要

A three-dimensional electrochemical origami-paper integrated cell chamber (3DP EO-PICC) that detects methamphetamine, an illicit drug, at a minimum concentration of 0.01 µg/mL is presented in this study. The sensor was made from an ecologically friendly polylactic acid (PLA) filament with a single foldable origami flap and a central reaction chamber for loading samples onto the paper printed electrode. The electrode acts as a reaction chamber where analyte interact with the pre-deposited zinc oxide & graphene oxide nanocomposite (ZnO-GO NCs), which is manufactured using a chemical reduction technique. Cyclic voltammetry (CV), linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS) were used for the detection of methamphetamine (Meth), proving the sensor’s excellent sensitivity. Integrating 3D printing with nano-biosensing devices allow accurate spatial positioning of nanoscale components, improves analyte interaction via greater surface area, and enables adjustable sensor designs. This technique facilitates the inclusion of complicated structures into sensor design while also enabling scalable, cost-effective manufacture, opening the way for creative and practical biosensing platforms.

Graphical abstract