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<p>Inertial microfluidics is a passive particle manipulation technique, excelling in simplicity, precision, and high throughput. However, its restricted adaptability to varying particle sizes has limited its broader application. This study presents numerical simulations on a stretchable inertial microfluidic device that dynamically adjusts channel dimensions, enabling tunable particle focusing and separation. Building upon the experimental work by Fallahi et al. (Analytical Chemistry, 2020), we incorporate advanced numerical simulations to evaluate how channel stretching influences particle migration dynamics. We investigate the inertial focusing of 15&#xa0;µm&#xa0;particles and the separation of 10-µm and 15-µm particles in a straight channel under varying stretching lengths. Stretching the channel length up to 6&#xa0;mm resulted in a near-complete focusing efficiency of almost 100%. Furthermore, increasing the channel length enhanced the effective separation of 10- and 15-µm&#xa0;particles, achieving 100% separation efficiency and purity. We identify an optimal stretching length that maximizes the separation efficiency, thereby confirming the device’s effectiveness. Qualitative and quantitative validation demonstrate excellent agreement between experimental and simulation results, with an accuracy of 99.82% and an average error of 0.18%, underscoring the reliability of the proposed model. The simulated stretchable device, capable of dynamically adjusting the channel dimensions in real time, opens up new perspectives and potential applications with enhanced tunability and performance of inertial manipulation, focusing, and separation of particles.</p>

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Numerical simulation and validation of stretchable inertial microfluidics for tunable particle focusing and separation

  • 期刊论文

  • 发表日期：

    2026年1月19日

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  • Shaghayegh Tavasoli,
  • M. Soltani,
  • Mohammad Kiani Shahvandi,
  • Navid Kashaninejad,
  • Nam-Trung Nguyen

摘要

Inertial microfluidics is a passive particle manipulation technique, excelling in simplicity, precision, and high throughput. However, its restricted adaptability to varying particle sizes has limited its broader application. This study presents numerical simulations on a stretchable inertial microfluidic device that dynamically adjusts channel dimensions, enabling tunable particle focusing and separation. Building upon the experimental work by Fallahi et al. (Analytical Chemistry, 2020), we incorporate advanced numerical simulations to evaluate how channel stretching influences particle migration dynamics. We investigate the inertial focusing of 15 µm particles and the separation of 10-µm and 15-µm particles in a straight channel under varying stretching lengths. Stretching the channel length up to 6 mm resulted in a near-complete focusing efficiency of almost 100%. Furthermore, increasing the channel length enhanced the effective separation of 10- and 15-µm particles, achieving 100% separation efficiency and purity. We identify an optimal stretching length that maximizes the separation efficiency, thereby confirming the device’s effectiveness. Qualitative and quantitative validation demonstrate excellent agreement between experimental and simulation results, with an accuracy of 99.82% and an average error of 0.18%, underscoring the reliability of the proposed model. The simulated stretchable device, capable of dynamically adjusting the channel dimensions in real time, opens up new perspectives and potential applications with enhanced tunability and performance of inertial manipulation, focusing, and separation of particles.