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<p>The development of digital microfluidics has inspired significant advancements in diverse applications such as virus detection, molecular hybridization, and chemical reactions. The capabilities of digital microfluidics, taking Electrowetting-on-Dielectric (EWOD) for example, are precise handling and detecting targets based on the fundamental manipulations such as transportation, merging, mixing, and splitting of droplets. However, digital microfluidic systems suffer from complex electrode layouts, poor dynamic performance, and low-efficiency droplet manipulation. To address these limitations, we present a digital microfluidic system with enhanced dynamic properties using unidirectional emission surface acoustic waves. Surface acoustic wave device with resonance frequency of 300&#xa0;MHz has been carefully designed with an acoustic reflector next to one end driving path from the other end, which is demonstrated as long as 600 times the wavelength for droplet transportation. By arranging the SAW array, the system enables precise and high-speed droplet transportation within a large programmed area. A smart platform is developed to automatically program and control droplets with preplanned routes. The SAW droplet manipulation system has shown excellent performance in high speed, ultra-long pathways, and automatic navigation, greatly promoting the acoustic manipulation advancements for biomedical research and chemical engineering.</p>

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Acoustic manipulations of droplets with high-speed automatic route planning and navigation

  • 期刊论文

  • 发表日期：

    2025年7月11日

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  • Shuchang Liu,
  • Luyao Li,
  • Shuying Wang,
  • Bohan Liang,
  • Hao Zhang,
  • Weiwei Cui

摘要

The development of digital microfluidics has inspired significant advancements in diverse applications such as virus detection, molecular hybridization, and chemical reactions. The capabilities of digital microfluidics, taking Electrowetting-on-Dielectric (EWOD) for example, are precise handling and detecting targets based on the fundamental manipulations such as transportation, merging, mixing, and splitting of droplets. However, digital microfluidic systems suffer from complex electrode layouts, poor dynamic performance, and low-efficiency droplet manipulation. To address these limitations, we present a digital microfluidic system with enhanced dynamic properties using unidirectional emission surface acoustic waves. Surface acoustic wave device with resonance frequency of 300 MHz has been carefully designed with an acoustic reflector next to one end driving path from the other end, which is demonstrated as long as 600 times the wavelength for droplet transportation. By arranging the SAW array, the system enables precise and high-speed droplet transportation within a large programmed area. A smart platform is developed to automatically program and control droplets with preplanned routes. The SAW droplet manipulation system has shown excellent performance in high speed, ultra-long pathways, and automatic navigation, greatly promoting the acoustic manipulation advancements for biomedical research and chemical engineering.