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Purpose <p>To retrospectively evaluate the diagnostic performance and safety of ultrasound (US)-guided biopsy for thoracic lesions, exploring the potential role of contrast-enhanced US (CEUS) for tissue sampling accuracy.</p> Methods <p>This single-center retrospective study included 14 consecutive cases that underwent US-guided biopsy for thoracic lesions. The mean age was 68 ± 12&#xa0;years (8 males, 6 females). Lesions were located in the lung (n = 3), mediastinum (n = 4), chest wall (n = 3), and rib (n = 4). Biopsies were performed using an 18- or 20-gauge core needle under B-mode and color Doppler guidance. CEUS using Sonazoid<sup>®</sup> was employed in three cases: two with suspected necrosis and one with renal impairment. The primary outcome measures were technical and clinical success, diagnostic accuracy, and complications.</p> Results <p>Technical and clinical success rates were both 100% (14/14). Diagnostic accuracy was 92.8% (13/14) with a false-negative rate of 9.1% (1/11 malignant cases). Median biopsies: 2 (range: 1–4); mean procedure time: 24.0 ± 12.5&#xa0;min. Diagnoses included three benign and 11 malignant lesions. One complication (7.1%) occurred: mild pneumothorax managed conservatively. This case required four biopsies due to necrotic tissue sampling. CEUS-guided cases achieved diagnosis within three biopsies without complications, with successful identification of viable tissue in all cases.</p> Conclusion <p>US-guided biopsy for thoracic lesions demonstrates high success rates and safety comparable to those in the literature. In this limited series, CEUS showed potential for identifying viable tissue in cases with suspected necrosis and enabled lesion evaluation while minimizing iodinated contrast exposure in patients with renal impairment. Validation in larger studies is needed.</p>

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Ultrasound-guided biopsy for thoracic lesions: diagnostic performance, safety, and potential role of contrast-enhanced ultrasound

  • 期刊论文

  • 发表日期：

    2026年5月23日

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  • Masato Saito,
  • Hiroki Okuda,
  • Akemi Ohtani,
  • Hiroki Sato,
  • Kenichiro Nitta,
  • Kisara Koike,
  • Masanori Someya

摘要

Purpose

To retrospectively evaluate the diagnostic performance and safety of ultrasound (US)-guided biopsy for thoracic lesions, exploring the potential role of contrast-enhanced US (CEUS) for tissue sampling accuracy.

Methods

This single-center retrospective study included 14 consecutive cases that underwent US-guided biopsy for thoracic lesions. The mean age was 68 ± 12 years (8 males, 6 females). Lesions were located in the lung (n = 3), mediastinum (n = 4), chest wall (n = 3), and rib (n = 4). Biopsies were performed using an 18- or 20-gauge core needle under B-mode and color Doppler guidance. CEUS using Sonazoid® was employed in three cases: two with suspected necrosis and one with renal impairment. The primary outcome measures were technical and clinical success, diagnostic accuracy, and complications.

Results

Technical and clinical success rates were both 100% (14/14). Diagnostic accuracy was 92.8% (13/14) with a false-negative rate of 9.1% (1/11 malignant cases). Median biopsies: 2 (range: 1–4); mean procedure time: 24.0 ± 12.5 min. Diagnoses included three benign and 11 malignant lesions. One complication (7.1%) occurred: mild pneumothorax managed conservatively. This case required four biopsies due to necrotic tissue sampling. CEUS-guided cases achieved diagnosis within three biopsies without complications, with successful identification of viable tissue in all cases.

Conclusion

US-guided biopsy for thoracic lesions demonstrates high success rates and safety comparable to those in the literature. In this limited series, CEUS showed potential for identifying viable tissue in cases with suspected necrosis and enabled lesion evaluation while minimizing iodinated contrast exposure in patients with renal impairment. Validation in larger studies is needed.