<p>Antibiotic resistance poses a critical global health threat, demanding robust surveillance systems to monitor its prevalence, patterns, and trends. The One Health approach has emerged as a comprehensive framework, emphasizing the interconnectedness of human health, animal health, and the environment in addressing this complex issue. This article explores the potential of One Health-based antibiotic resistance surveillance, integrating big data analytics and interdisciplinary collaboration. Challenges and opportunities in harmonizing surveillance efforts across sectors are discussed, underscoring the importance of data sharing and standardization. Advanced technologies like genomics and metagenomics are examined for understanding the genetic basis of antibiotic resistance and tracking its spread. The article also highlights the potential of real-time monitoring and early warning systems to inform evidence-based policies and antimicrobial stewardship programs. By analyzing the state-of-the-art in antibiotic resistance surveillance, this article sheds light on the transformative potential of One Health approaches, leveraging big data and interdisciplinary collaboration to combat antibiotic resistance effectively. The urgency of adopting a united global effort to safeguard the efficacy of antibiotics for future generations is emphasized.</p>