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Background <p>The National Tuberculosis Program (NTP) has evolved into a multidisciplinary global research domain over the past century; however, a comprehensive bibliometric synthesis remains lacking. This study aims to systematically map the intellectual structure, thematic evolution, and global collaboration networks shaping NTP-related research.</p> Methods <p>A total of 5,895 original research articles published between 1907 and 2025 were retrieved from the Scopus database. Bibliometric analyses were conducted using Bibliometrix (R-package v4.2.1), VOSviewer (v1.6.20), and CiteSpace (v6.3.R2, China). The investigation employed performance indicators, Bradford’s Law, keyword co-occurrence, Walktrap clustering, reference co-citation, and trend analysis to examine productivity, influence, and thematic development.</p> Results <p>NTP research demonstrated a steady annual growth rate of 4.42%, with 32.42% of publications involving international collaboration. The USA, India, and the UK were the most prolific and influential contributors. Bradford’s Law revealed 24 core journals accounting for one-third of total output. Keyword analysis identified dominant foci such as <i>tuberculosis</i>, <i>HIV</i>, and <i>treatment outcome</i>. Thematic evolution showed a transition from early BCG and epidemiological studies to cross-sectional designs, policy implementation, and elimination strategies. Reference co-citation clustering revealed eight conceptual groups—such as “Global Burden,” “Digital Medication Event Reminder,” and “Direct Benefit Transfer”—while thematic mapping positioned “tuberculosis” as a central yet developing theme. Emerging research areas included <i>bedaquiline</i>, <i>COVID-19</i>, <i>implementation science</i>, and <i>preventive therapy</i>.</p> Conclusion <p>This study delineates the historical trajectory and future directions of NTP research, revealing key contributors, evolving priorities, and collaborative patterns. The findings provide a strategic framework for advancing tuberculosis research and policy through integrated, evidence-based, and globally coordinated approaches.</p>

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Research hotspots, intellectual structures, and emerging themes in national tuberculosis program studies: a multi-dimensional analysis of global trends and directions

  • 期刊论文

  • 发表日期：

    2026年2月4日

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  • Siddig Ibrahim Abdelwahab,
  • Manal Mohamed Elhassan Taha,
  • Hazem Mathkour,
  • Edrous Alamer,
  • Saleh Mohammad Abdullah,
  • Saeed Alshahrani,
  • Nizar A. Khamjan,
  • Abdullah Farasani,
  • Ahmed S. Alamer,
  • Jobran M. Moshi,
  • Khaled A. Sahli,
  • Mohammed Jeraiby,
  • Marwa Qadri,
  • Abdulwahab Binjomah,
  • Khloud H. Alsaadi,
  • Hussam M. Shubaily

摘要

Background

The National Tuberculosis Program (NTP) has evolved into a multidisciplinary global research domain over the past century; however, a comprehensive bibliometric synthesis remains lacking. This study aims to systematically map the intellectual structure, thematic evolution, and global collaboration networks shaping NTP-related research.

Methods

A total of 5,895 original research articles published between 1907 and 2025 were retrieved from the Scopus database. Bibliometric analyses were conducted using Bibliometrix (R-package v4.2.1), VOSviewer (v1.6.20), and CiteSpace (v6.3.R2, China). The investigation employed performance indicators, Bradford’s Law, keyword co-occurrence, Walktrap clustering, reference co-citation, and trend analysis to examine productivity, influence, and thematic development.

Results

NTP research demonstrated a steady annual growth rate of 4.42%, with 32.42% of publications involving international collaboration. The USA, India, and the UK were the most prolific and influential contributors. Bradford’s Law revealed 24 core journals accounting for one-third of total output. Keyword analysis identified dominant foci such as tuberculosis, HIV, and treatment outcome. Thematic evolution showed a transition from early BCG and epidemiological studies to cross-sectional designs, policy implementation, and elimination strategies. Reference co-citation clustering revealed eight conceptual groups—such as “Global Burden,” “Digital Medication Event Reminder,” and “Direct Benefit Transfer”—while thematic mapping positioned “tuberculosis” as a central yet developing theme. Emerging research areas included bedaquiline, COVID-19, implementation science, and preventive therapy.

Conclusion

This study delineates the historical trajectory and future directions of NTP research, revealing key contributors, evolving priorities, and collaborative patterns. The findings provide a strategic framework for advancing tuberculosis research and policy through integrated, evidence-based, and globally coordinated approaches.