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Aim <p>Despite strict regulation, Germany is among the countries with the highest per capita consumption of opioid analgesics. This explorative analysis aims to describe the probability of opioid discontinuation in relation to the duration of opioid prescription in a large population-based sample with long-term opioid prescriptions for chronic non-cancer pain (CNCP).</p> Subject and methods <p>Administrative claims data of a large nationwide statutory health insurance of patients with opioid prescriptions in two successive quarters were analyzed retrospectively. The selection period was from January 2018 to June 2019. The date of the first opioid prescription in the selection period marked the start of the 24-month observation period for each patient. Eligible categories of diagnoses appraised by the German guideline for long-term opioid therapy in chronic non-cancer pain were identified in inpatient and outpatient claims data.</p> Results <p>Inclusion criteria were met by 113,476 patients with long-term opioid prescriptions (75% female, mean age 72&#xa0;years). Diagnoses in line with the German guideline were identified in 75% to 80% of patients. Half of the study population (49%) had received opioid prescriptions for at least 1 year prior to the observation period. The probability of opioid discontinuation decreased from 39% in patients with prior opioid treatment for less than 1 year to 10% for patients with prior opioid treatment in at least 1 year.</p> Conclusion <p>The results give important insights into patient structure and the probability of opioid discontinuation of patients with long-term opioid prescriptions for CNCP in Germany.</p>

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Long-term opioid prescription and opioid discontinuation in patients with chronic non-cancer pain in Germany: a retrospective analysis based on administrative claims data

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  • 发表日期：

    2025年12月16日

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  • Silke Neusser,
  • Anja Niemann,
  • Nils Schrader,
  • Nikola Blase,
  • Milena Weitzel,
  • Carina Abels,
  • Christian Speckemeier,
  • Anja Neumann,
  • Cordula Riederer,
  • Joachim Nadstawek,
  • Wolfgang Straßmeir,
  • J. Wasem

摘要

Aim

Despite strict regulation, Germany is among the countries with the highest per capita consumption of opioid analgesics. This explorative analysis aims to describe the probability of opioid discontinuation in relation to the duration of opioid prescription in a large population-based sample with long-term opioid prescriptions for chronic non-cancer pain (CNCP).

Subject and methods

Administrative claims data of a large nationwide statutory health insurance of patients with opioid prescriptions in two successive quarters were analyzed retrospectively. The selection period was from January 2018 to June 2019. The date of the first opioid prescription in the selection period marked the start of the 24-month observation period for each patient. Eligible categories of diagnoses appraised by the German guideline for long-term opioid therapy in chronic non-cancer pain were identified in inpatient and outpatient claims data.

Results

Inclusion criteria were met by 113,476 patients with long-term opioid prescriptions (75% female, mean age 72 years). Diagnoses in line with the German guideline were identified in 75% to 80% of patients. Half of the study population (49%) had received opioid prescriptions for at least 1 year prior to the observation period. The probability of opioid discontinuation decreased from 39% in patients with prior opioid treatment for less than 1 year to 10% for patients with prior opioid treatment in at least 1 year.

Conclusion

The results give important insights into patient structure and the probability of opioid discontinuation of patients with long-term opioid prescriptions for CNCP in Germany.