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Background <p>Photodynamic therapy (PDT) is a salvage endoscopic treatment option for local failure after chemoradiotherapy for esophageal squamous cell carcinoma (ESCC). PDT is usually performed using ordinary-sized conventional endoscopes (CEs); however, some patients with local failure have esophageal stenosis caused by chemoradiotherapy or endoscopic resection. In such cases, an ultra-thin endoscope (UTE) is sometimes used, but the efficacy and safety of PDT performed with UTEs (UTE-PDT) remain unclear. In this study, we compared the treatment outcomes of UTE-PDT with those of PDT using CEs (CE-PDT).</p> Methods <p>This retrospective study analyzed patients who underwent talaporfin sodium-based PDT for histologically confirmed local ESCC failure between October 2015 and June 2022. Short-term outcomes, including the local complete response (L-CR) rate and adverse events, were compared between UTE-PDT and CE-PDT.</p> Results <p>In total, eight patients underwent UTE-PDT and <i>81</i> underwent CE-PDT. L-CR rates were 50.0% and 59.3% for the UTE-PDT and CE-PDT groups, respectively. The L-CR rates for lesions ≤ 20&#xa0;mm were 50.0% (4/8) and 63.4% (45/71) in the UTE-PDT and CE-PDT groups, and for cT1 lesions, they were 57.1% (4/7) and 63.2% (43/68), respectively. Adverse events included esophageal pain (12.5% and <i>39.5%</i>) and esophageal stenosis (12.5% and <i>4.9%</i>) in the UTE-PDT and CE-PDT groups, respectively; however, all were grade ≤ 2.</p> Conclusions <p>UTE-PDT for local failure after chemoradiotherapy for ESCC showed short-term outcomes that did not differ substantially from those of CE-PDT and may represent a potential therapeutic option for patients with no alternative treatment options.</p>

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Efficacy and safety of photodynamic therapy using an ultra-thin endoscope for local failure with esophageal stenosis after chemoradiotherapy for esophageal cancer

  • 期刊论文

  • 发表日期：

    2026年6月2日

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  • Aiji Hattori,
  • Tomohiro Kadota,
  • Hiroki Yamashita,
  • Nobuhisa Minakata,
  • Takashi Watanabe,
  • Atsushi Inaba,
  • Hironori Sunakawa,
  • Keiichiro Nakajo,
  • Kensuke Shinmura,
  • Tomonori Yano

摘要

Background

Photodynamic therapy (PDT) is a salvage endoscopic treatment option for local failure after chemoradiotherapy for esophageal squamous cell carcinoma (ESCC). PDT is usually performed using ordinary-sized conventional endoscopes (CEs); however, some patients with local failure have esophageal stenosis caused by chemoradiotherapy or endoscopic resection. In such cases, an ultra-thin endoscope (UTE) is sometimes used, but the efficacy and safety of PDT performed with UTEs (UTE-PDT) remain unclear. In this study, we compared the treatment outcomes of UTE-PDT with those of PDT using CEs (CE-PDT).

Methods

This retrospective study analyzed patients who underwent talaporfin sodium-based PDT for histologically confirmed local ESCC failure between October 2015 and June 2022. Short-term outcomes, including the local complete response (L-CR) rate and adverse events, were compared between UTE-PDT and CE-PDT.

Results

In total, eight patients underwent UTE-PDT and 81 underwent CE-PDT. L-CR rates were 50.0% and 59.3% for the UTE-PDT and CE-PDT groups, respectively. The L-CR rates for lesions ≤ 20 mm were 50.0% (4/8) and 63.4% (45/71) in the UTE-PDT and CE-PDT groups, and for cT1 lesions, they were 57.1% (4/7) and 63.2% (43/68), respectively. Adverse events included esophageal pain (12.5% and 39.5%) and esophageal stenosis (12.5% and 4.9%) in the UTE-PDT and CE-PDT groups, respectively; however, all were grade ≤ 2.

Conclusions

UTE-PDT for local failure after chemoradiotherapy for ESCC showed short-term outcomes that did not differ substantially from those of CE-PDT and may represent a potential therapeutic option for patients with no alternative treatment options.