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Purpose <p>This retrospective cohort compared the cumulative probability of success for glaucoma drainage device (GDD) implantation in pediatric and adult patients.</p> Study design <p>This retrospective study enrolled adult and pediatric patients who had received a GDD between January 1, 1985 and December 31, 2017.</p> Methods <p>Kaplan-Meier method was used to estimate the cumulative probability of success in the pediatric and adult patients. Successful intraocular pressure (IOP) control was defined as (i) a 20% reduction from baseline and (ii) IOP&gt;6 and &lt;18. Inadequate IOP control and failure were defined as a violation of these two criteria over two consecutive visits. Cox proportional hazards models enabled assessing the influence of sex, GDD location, and GDD type on IOP control.</p> Results <p>A total of 425 adult eyes from 372 individuals and 41 pediatric eyes from 28 individuals were included. The median follow-up time was 55 months for adults and 87 months for children. Superior temporal GDD placement was most employed for both (<i>p</i>=0.16). Adults were more likely to receive a Baerveldt 350 (<i>p</i>=0.04) and children were more likely to receive an Ahmed S2 (<i>p</i>&lt;0.001). Adults and children had a median survival time of 2.99 and 0.82, respectively, and did not have a statistically significant difference in GDD failure rate (<i>p</i>=0.18). Additionally, sex, GDD location, and GDD type did not affect the success rate.</p> Conclusions <p>Children and adults had a similar cumulative probability of success following GDD implantation. This study found that GDD type, GDD location, and glaucoma type did not influence the probability of successful IOP control.</p>

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A single center experience of intraocular pressure control with glaucoma drainage device use in pediatric and adult patients

  • 期刊论文

  • 发表日期：

    2025年6月21日

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  • Armin Garmany,
  • Sepideh Jamali Dogahe,
  • Kit Knier,
  • Felix Kung,
  • Jason Sargent,
  • David Hodge,
  • Cheryl Khanna

摘要

Purpose

This retrospective cohort compared the cumulative probability of success for glaucoma drainage device (GDD) implantation in pediatric and adult patients.

Study design

This retrospective study enrolled adult and pediatric patients who had received a GDD between January 1, 1985 and December 31, 2017.

Methods

Kaplan-Meier method was used to estimate the cumulative probability of success in the pediatric and adult patients. Successful intraocular pressure (IOP) control was defined as (i) a 20% reduction from baseline and (ii) IOP>6 and <18. Inadequate IOP control and failure were defined as a violation of these two criteria over two consecutive visits. Cox proportional hazards models enabled assessing the influence of sex, GDD location, and GDD type on IOP control.

Results

A total of 425 adult eyes from 372 individuals and 41 pediatric eyes from 28 individuals were included. The median follow-up time was 55 months for adults and 87 months for children. Superior temporal GDD placement was most employed for both (p=0.16). Adults were more likely to receive a Baerveldt 350 (p=0.04) and children were more likely to receive an Ahmed S2 (p<0.001). Adults and children had a median survival time of 2.99 and 0.82, respectively, and did not have a statistically significant difference in GDD failure rate (p=0.18). Additionally, sex, GDD location, and GDD type did not affect the success rate.

Conclusions

Children and adults had a similar cumulative probability of success following GDD implantation. This study found that GDD type, GDD location, and glaucoma type did not influence the probability of successful IOP control.