Scholarlink

Purpose <p>The aim of this study was to investigate the clinical characteristics of acute corneal hydrops (ACH) in patients with keratoconus and to examine the risk factors for persistent corneal edema.</p> Study design <p>Retrospective observational study.</p> Methods <p>The study included 98 patients (106 eyes) diagnosed with ACH between February 2009 and August 2023 at Kyoto Prefectural University of Medicine. Seventy-seven eyes with clear data on both onset and resolution were analyzed for the risk factors for persistent corneal edema. Clinical characteristics, duration of corneal edema, and associated risk factors such as seasonal variations, edema area, allergic diseases, eye rubbing, and neurodevelopmental disorders (including Down syndrome) were collected and analyzed.</p> Results <p>The study included 90 male (91.8%) and 8 female (8.2%) patients. The mean (SD) age at ACH onset was 33.3 (13.8) years (range, 14–80). ACH occurred most prevalently during the spring season (n = 39, 36.8%). Allergic diseases were present in 59 eyes (55.7%); eye rubbing, in 58 eyes (54.7%); and neurodevelopmental disorders, in 9 eyes (8.5%). Corneal edema resolved within 3 months in 55 eyes (71.4%), whereas it persisted for over 3 months in 22 eyes (28.6%). Multivariate analysis showed that a large edema area, ≥50%, was a significant risk factor for persistent corneal edema of more than 3 months in ACH patients (odds ratio, 7.41; 95% CI, 1.95–33.02; <i>P</i> = .005).</p> Conclusion <p>Large corneal edema at ACH onset carries a high risk of persistent corneal edema. These patients should be managed more carefully to resolve the corneal edema earlier.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Identification of risk factors for persistent corneal edema associated with acute corneal hydrops in keratoconus

  • 期刊论文

  • 发表日期：

    2025年4月18日

查看全文
  • Takaaki Aichi,
  • Koji Kitazawa,
  • Renako Kozaki,
  • Yohei Yamashita,
  • Motohiro Itoi,
  • Kengo Yoshii,
  • Keiko Yamagishi,
  • Hisayo Higashihara,
  • Mari Osawa,
  • Yoko Hyakutake,
  • Hideki Koizumi,
  • Chie Sotozono

摘要

Purpose

The aim of this study was to investigate the clinical characteristics of acute corneal hydrops (ACH) in patients with keratoconus and to examine the risk factors for persistent corneal edema.

Study design

Retrospective observational study.

Methods

The study included 98 patients (106 eyes) diagnosed with ACH between February 2009 and August 2023 at Kyoto Prefectural University of Medicine. Seventy-seven eyes with clear data on both onset and resolution were analyzed for the risk factors for persistent corneal edema. Clinical characteristics, duration of corneal edema, and associated risk factors such as seasonal variations, edema area, allergic diseases, eye rubbing, and neurodevelopmental disorders (including Down syndrome) were collected and analyzed.

Results

The study included 90 male (91.8%) and 8 female (8.2%) patients. The mean (SD) age at ACH onset was 33.3 (13.8) years (range, 14–80). ACH occurred most prevalently during the spring season (n = 39, 36.8%). Allergic diseases were present in 59 eyes (55.7%); eye rubbing, in 58 eyes (54.7%); and neurodevelopmental disorders, in 9 eyes (8.5%). Corneal edema resolved within 3 months in 55 eyes (71.4%), whereas it persisted for over 3 months in 22 eyes (28.6%). Multivariate analysis showed that a large edema area, ≥50%, was a significant risk factor for persistent corneal edema of more than 3 months in ACH patients (odds ratio, 7.41; 95% CI, 1.95–33.02; P = .005).

Conclusion

Large corneal edema at ACH onset carries a high risk of persistent corneal edema. These patients should be managed more carefully to resolve the corneal edema earlier.