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<p>Exposure to stress causes the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER), disrupts ER homeostasis and ultimately leads to ER stress. In this study, the potential therapeutic effects of two important defence and developmental hormones, jasmonic acid (JA) and melatonin (MEL), in alleviating cellular, physiological and molecular responses to ER stress were investigated in tunicamycin (TM)-induced tomato seedlings.</p><p>TM-induced ER stress negatively affected the morphological development of the plants. The JA + MEL combination was remarkable in that it increased plant growth above the control. JA + MEL application increased GTS from 70% to 92%. The combined JA + MEL treatment decreased TM-induced <i>lyPARP1</i> and <i>lyRAD51</i> gene expression to control levels, while <i>lyKU70</i> and <i>lyBARD1</i> gene expression levels increased. JA applied externally was found to be effective to ER stress was particularly effective in DNA repair and restoration of chlorophyll damage, while MEL application was significantly involved in antioxidant defence signalling and attenuation of ER stress. The combined application of JA and MEL was found to be synergistic in reducing ER stress, stabilising the Unfolded Protein Response (UPR) and oxidative stress, and preventing DNA damage, bringing all parameters close to control. When all our results were evaluated together, it was predicted that the combination of JA and MEL could be used as a&#xa0;potential strategy in the treatment of ER stress-induced damage in tomato seedlings and would provide valuable cellular and molecular data for the development of breeding and control strategies against yield loss in plants.</p>

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Potential Mitigating Effects of Jasmonic Acid and Melatonin On Endoplasmic Reticulum Stress of Tomato

  • 期刊论文

  • 发表日期：

    2026年1月8日

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  • Kamile Ulukapı,
  • Zeynep Banu Doganlar,
  • Ozlem Sahın,
  • Ayse Gul Nasırcılar

摘要

Exposure to stress causes the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER), disrupts ER homeostasis and ultimately leads to ER stress. In this study, the potential therapeutic effects of two important defence and developmental hormones, jasmonic acid (JA) and melatonin (MEL), in alleviating cellular, physiological and molecular responses to ER stress were investigated in tunicamycin (TM)-induced tomato seedlings.

TM-induced ER stress negatively affected the morphological development of the plants. The JA + MEL combination was remarkable in that it increased plant growth above the control. JA + MEL application increased GTS from 70% to 92%. The combined JA + MEL treatment decreased TM-induced lyPARP1 and lyRAD51 gene expression to control levels, while lyKU70 and lyBARD1 gene expression levels increased. JA applied externally was found to be effective to ER stress was particularly effective in DNA repair and restoration of chlorophyll damage, while MEL application was significantly involved in antioxidant defence signalling and attenuation of ER stress. The combined application of JA and MEL was found to be synergistic in reducing ER stress, stabilising the Unfolded Protein Response (UPR) and oxidative stress, and preventing DNA damage, bringing all parameters close to control. When all our results were evaluated together, it was predicted that the combination of JA and MEL could be used as a potential strategy in the treatment of ER stress-induced damage in tomato seedlings and would provide valuable cellular and molecular data for the development of breeding and control strategies against yield loss in plants.