Scholarlink

<p>Plants have developed sophisticated processes for metal homeostasis, balancing metal absorption for beneficial function with toxicity avoidance. In this review, new advances in metal transport, chelation, and signaling processes have been synthesized, with an emphasis placed on dynamically regulated key transporter superfamilies (ZIP, NRAMP, HMA, CDF) and chelators (e.g., metallothioneins and phytochelatins). Well-established processes, these have recently been postulated to have a&#xa0;much more sophisticated level of homeostatic regulation than initially proposed, with real-time variation in environment and species specificity having an influence. A&#xa0;critical breakthrough in this review is venturing into underexploited regulative layers, namely post-translational modifications’ contribution to metal transporter function—an emerging and understudied area in plant physiology. Furthermore, we reveal prospective advancements in omics-inspired innovations, since transcriptome and proteomic analyses uncover concealed regulatory networks that control metal tolerance. These advancements facilitate the development of next-generation tools in biotechnology, such as CRISPR/Cas9 gene editing and synthetic biology techniques that modify metal stress responses in plants. Apart from theoretical advances, this review formulates actionable strategies for sustainable agriculture. We redefine phytoremediation with engineered hyperaccumulators for effective metal extraction and selective biofortification strategies, in which useful minerals are selectively accumulated and noxious ones avoided. In the future, a&#xa0;union of AI-facilitated computational simulations with information in omics will revolutionize predictive capabilities, and with unparalleled accuracy, allow for anticipation and engineering of plant response to metal toxicity. Not only will such a&#xa0;synergy contribute to fundamental information, but it will yield a&#xa0;futuristic blueprint for overcoming soil pollution, food security, and climate adaptability.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Regulation of Heavy Metal Balance in Plants: Roles of Transporters, Chelators, and Signaling Mechanisms

  • 期刊论文

  • 发表日期：

    2025年7月2日

查看全文
  • Hadiseh Sadat Hosseini Pouya,
  • Fatemeh Zare,
  • Parviz Heidari

摘要

Plants have developed sophisticated processes for metal homeostasis, balancing metal absorption for beneficial function with toxicity avoidance. In this review, new advances in metal transport, chelation, and signaling processes have been synthesized, with an emphasis placed on dynamically regulated key transporter superfamilies (ZIP, NRAMP, HMA, CDF) and chelators (e.g., metallothioneins and phytochelatins). Well-established processes, these have recently been postulated to have a much more sophisticated level of homeostatic regulation than initially proposed, with real-time variation in environment and species specificity having an influence. A critical breakthrough in this review is venturing into underexploited regulative layers, namely post-translational modifications’ contribution to metal transporter function—an emerging and understudied area in plant physiology. Furthermore, we reveal prospective advancements in omics-inspired innovations, since transcriptome and proteomic analyses uncover concealed regulatory networks that control metal tolerance. These advancements facilitate the development of next-generation tools in biotechnology, such as CRISPR/Cas9 gene editing and synthetic biology techniques that modify metal stress responses in plants. Apart from theoretical advances, this review formulates actionable strategies for sustainable agriculture. We redefine phytoremediation with engineered hyperaccumulators for effective metal extraction and selective biofortification strategies, in which useful minerals are selectively accumulated and noxious ones avoided. In the future, a union of AI-facilitated computational simulations with information in omics will revolutionize predictive capabilities, and with unparalleled accuracy, allow for anticipation and engineering of plant response to metal toxicity. Not only will such a synergy contribute to fundamental information, but it will yield a futuristic blueprint for overcoming soil pollution, food security, and climate adaptability.