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<p>Two types of physically adsorbed hybrid coatings for the inner walls of fused silica capillaries using chitosan and gold nanoparticles (GNPs) are proposed for the selective electrophoretic separation of biologically active substances. The first approach involves the formation of a coating with chitosan-modified citrate-stabilized GNPs (cGNPs@CS). The second approach involves the sequential deposition of positively charged polydiallyldimethylammonium chloride (PDDA) and negatively charged citrate-stabilized gold nanoparticles (cGNPs) followed by functionalization with chitosan. The resulting cGNPs@CS-based coatings effectively shield capillary silanol groups in the pH range of 2 to 7, which is unattainable with a chitosan monolayer. The hybrid coatings provided high resolution of dansylated amino acid derivatives and increased resolution factors in the electrophoretic separation of carvedilol enantiomers.</p>

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Chitosan and Gold Nanoparticle-Based Coatings for Electrophoretic Separation of Biologically Active Compounds

  • 期刊论文

  • 发表日期：

    2025年12月8日

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  • E. R. Ziangirova,
  • E. A. Kolobova,
  • E. V. Solovyeva,
  • L. A. Kartsova

摘要

Two types of physically adsorbed hybrid coatings for the inner walls of fused silica capillaries using chitosan and gold nanoparticles (GNPs) are proposed for the selective electrophoretic separation of biologically active substances. The first approach involves the formation of a coating with chitosan-modified citrate-stabilized GNPs (cGNPs@CS). The second approach involves the sequential deposition of positively charged polydiallyldimethylammonium chloride (PDDA) and negatively charged citrate-stabilized gold nanoparticles (cGNPs) followed by functionalization with chitosan. The resulting cGNPs@CS-based coatings effectively shield capillary silanol groups in the pH range of 2 to 7, which is unattainable with a chitosan monolayer. The hybrid coatings provided high resolution of dansylated amino acid derivatives and increased resolution factors in the electrophoretic separation of carvedilol enantiomers.