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<p>Superficially porous silica microspheres (SPSMs) with a dendritic mesoporous shell were successfully synthesized and functionalized with poly(2-(tert-butylamino)ethyl methacrylate) (PTBAEMA) brushes for application as high-performance liquid chromatography (HPLC) stationary phases. The particle size and shell morphology of the SPSMs were precisely tailored by adjusting the concentrations of tetraethyl orthosilicate (TEOS) and ammonia, as well as the TEOS addition rate. The optimized SPSM-PTBAEMA column exhibited excellent mechanical stability, as evidenced by the linear relationships observed between flow rate and column backpressure, as well as between column temperature and backpressure. Notably, the SPSM-PTBAEMA column achieved efficient separation of alkylbenzenes and polycyclic aromatic hydrocarbons (PAHs) under optimal chromatographic conditions. It demonstrated high resolution, with the chromatographic peaks of alkylbenzenes achieving resolutions between 1.5 and 5. Additionally, the column exhibited efficiency up to 59,100 plates/m for 1-phenylhexane and 64,610 plates/m for chrysene. These findings highlight the column’s superior performance in reverse-phase separations, offering excellent selectivity and stability across a diverse range of hydrophobic compounds. Overall, the study confirms the potential of SPSM-PTBAEMA as a highly effective stationary phase for HPLC, delivering robust and reliable performance in the separation of complex hydrophobic analytes.</p>

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Development of Superficially Porous Silica Core–Shell Particles Functionalized with Poly(2-(tert-butylamino)ethyl Methacrylate) Polymer Brushes for Enhanced Chromatographic Separation

  • 期刊论文

  • 发表日期：

    2025年9月15日

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  • Khalid M. Alotaibi,
  • Elham Bajuayfir,
  • Arun Kumar Shukla,
  • Ahmad Aqel,
  • Amal M. Al-Mohaimeed,
  • Abdullah M. Alswieleh,
  • Salman S.Alotaibi

摘要

Superficially porous silica microspheres (SPSMs) with a dendritic mesoporous shell were successfully synthesized and functionalized with poly(2-(tert-butylamino)ethyl methacrylate) (PTBAEMA) brushes for application as high-performance liquid chromatography (HPLC) stationary phases. The particle size and shell morphology of the SPSMs were precisely tailored by adjusting the concentrations of tetraethyl orthosilicate (TEOS) and ammonia, as well as the TEOS addition rate. The optimized SPSM-PTBAEMA column exhibited excellent mechanical stability, as evidenced by the linear relationships observed between flow rate and column backpressure, as well as between column temperature and backpressure. Notably, the SPSM-PTBAEMA column achieved efficient separation of alkylbenzenes and polycyclic aromatic hydrocarbons (PAHs) under optimal chromatographic conditions. It demonstrated high resolution, with the chromatographic peaks of alkylbenzenes achieving resolutions between 1.5 and 5. Additionally, the column exhibited efficiency up to 59,100 plates/m for 1-phenylhexane and 64,610 plates/m for chrysene. These findings highlight the column’s superior performance in reverse-phase separations, offering excellent selectivity and stability across a diverse range of hydrophobic compounds. Overall, the study confirms the potential of SPSM-PTBAEMA as a highly effective stationary phase for HPLC, delivering robust and reliable performance in the separation of complex hydrophobic analytes.