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Objective <p>This study aimed to investigate the effect of NaCl and KCl salts on the phase transition in native collagen.</p> Materials and Methods <p>We studied native bovine tendons, which are 85% collagen, using solid-state NMR spectroscopy.</p> Results <p>It was found that adding the above salts lowers the phase transition temperature, indicating that this parameter is highly sensitive to ionic species.</p> Discussion <p>The observed phenomenon is explained by an increase in the rate of proton exchange (i) between water molecules and (ii) between water molecules and hydrogen atoms of collagen fibers, with which water forms hydrogen bonds. Accelerated exchange shortens the average lifetime of proton pairs and shifts the phase transition toward lower temperatures. Additional mechanisms that contribute to the averaging of local magnetic fields on the hydrogen nuclei of mobile water molecules are also discussed.</p>

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Effect of salts on phase transition in native tendon collagen – an NMR study

  • 期刊论文

  • 发表日期：

    2026年7月11日

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  • Alexander M. Panich

摘要

Objective

This study aimed to investigate the effect of NaCl and KCl salts on the phase transition in native collagen.

Materials and Methods

We studied native bovine tendons, which are 85% collagen, using solid-state NMR spectroscopy.

Results

It was found that adding the above salts lowers the phase transition temperature, indicating that this parameter is highly sensitive to ionic species.

Discussion

The observed phenomenon is explained by an increase in the rate of proton exchange (i) between water molecules and (ii) between water molecules and hydrogen atoms of collagen fibers, with which water forms hydrogen bonds. Accelerated exchange shortens the average lifetime of proton pairs and shifts the phase transition toward lower temperatures. Additional mechanisms that contribute to the averaging of local magnetic fields on the hydrogen nuclei of mobile water molecules are also discussed.