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Purpose <p>To develop a dynamic contrast-enhanced (DCE) MRI protocol for imaging the aortic wall of abdominal aortic aneurysms (AAAs), and to investigate the repeatability and clinical correlation of novel biomarkers for rupture risk assessment.</p> Methods <p>A dedicated DCE protocol with black-blood contrast was applied to 20 patients with AAA, of which 16 underwent a second scan 6&#xa0;months later. Semiquantitative DCE-derived parameters in the aneurysm wall were calculated, assessed for test–retest repeatability using within-subject coefficient of variation (wCV), and correlated with clinical measures (aneurysm diameter and growth rate) using Spearman’s rank correlation.</p> Results <p>The developed protocol allows for accurate delineation of the aortic wall and calculation of semiquantitative DCE-derived parameters. The maximum enhancement (ME) and area under the curve (AUC) demonstrated good stability with wCVs of 14% and 18%, respectively. No significant correlations were found between DCE-derived parameters and clinical measures.</p> Conclusion <p>The derived DCE protocol enables repeatable assessment of semiquantitative parameters of the aortic wall in AAA patients. No correlation was found between DCE-derived parameters and clinical markers of aneurysm progression.</p>

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Black-blood dynamic contrast-enhanced MRI of abdominal aortic aneurysms

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月18日

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  • Wilhelm Stehling,
  • Eva Aalbregt,
  • Myrte Wennen,
  • Eric Schrauben,
  • Kak Khee Yeung,
  • Aart J. Nederveen,
  • Oliver J. Gurney-Champion

摘要

Purpose

To develop a dynamic contrast-enhanced (DCE) MRI protocol for imaging the aortic wall of abdominal aortic aneurysms (AAAs), and to investigate the repeatability and clinical correlation of novel biomarkers for rupture risk assessment.

Methods

A dedicated DCE protocol with black-blood contrast was applied to 20 patients with AAA, of which 16 underwent a second scan 6 months later. Semiquantitative DCE-derived parameters in the aneurysm wall were calculated, assessed for test–retest repeatability using within-subject coefficient of variation (wCV), and correlated with clinical measures (aneurysm diameter and growth rate) using Spearman’s rank correlation.

Results

The developed protocol allows for accurate delineation of the aortic wall and calculation of semiquantitative DCE-derived parameters. The maximum enhancement (ME) and area under the curve (AUC) demonstrated good stability with wCVs of 14% and 18%, respectively. No significant correlations were found between DCE-derived parameters and clinical measures.

Conclusion

The derived DCE protocol enables repeatable assessment of semiquantitative parameters of the aortic wall in AAA patients. No correlation was found between DCE-derived parameters and clinical markers of aneurysm progression.