Scholarlink

Objectives <p>To investigate the effects of gadolinium-based contrast agent (GBCA) on cardiac diffusion-weighted imaging (cDWI) and cDWI feasibility during the interval between GBCA administration and late gadolinium enhancement (LGE) imaging to streamline workflow.</p> Materials and methods <p>Phantoms containing varying GBCA concentration (0–1.0&#xa0;mM/L) were scanned with stimulated echo acquisition mode-based cDWI (STEAM-cDWI) with various heart rates (HRs) (30–200 beats/min) and second-order motion-compensated spin-echo-based cDWI (M2SE-cDWI) with various echo times (TEs) (75–500&#xa0;ms). For patient study, 9 patients underwent STEAM-cDWI and 13 underwent M2SE-cDWI before and after GBCA administration. Contrast ratio (CR) and contrast-to-noise ratio (CNR) between the left ventricular myocardium and cavity, and ADC values were assessed.</p> Results <p>In phantoms, higher GBCA concentration, lower HR, and prolonged TE reduced SI. In STEAM-cDWI, CR and CNR significantly reduced after GBCA administration (CR of b = 400, 2.29 [1.80–5.46] vs. 1.15 [0.78–1.29], p = 0.0004; CNR of b = 400, 7.58 [4.82–11.1] vs. 0.57 [− 1.34 to 1.35], p = 0.0006; respectively); ADC values remained unchanged. In M2SE-cDWI, ADC values significantly decreased after GBCA administration (1.62 [1.15–1.97] vs. 1.26 [1.12– 1.51], × 10<sup>–3</sup> mm<sup>2</sup>/s respectively, p = 0.004); only CR at b = 400 decreased significantly.</p> Discussion <p>cDWI is not recommended during the interval between GBCA administration and LGE imaging.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effects of gadolinium-based contrast agents on the cardiac diffusion-weighted images of phantoms and patients

  • 期刊论文

  • 发表日期：

    2026年4月10日

查看全文
  • Satonori Tsuneta,
  • Satoru Aono,
  • Jihun Kwon,
  • Masami Yoneyama,
  • Hiroki Uehara,
  • Takuya Aoike,
  • Sakae Takenaka,
  • Hidenori Koyano,
  • Noriyuki Fujima,
  • Toshiyuki Nagai,
  • Toshihisa Anzai,
  • Kazuyuki Minowa,
  • Kohsuke Kudo

摘要

Objectives

To investigate the effects of gadolinium-based contrast agent (GBCA) on cardiac diffusion-weighted imaging (cDWI) and cDWI feasibility during the interval between GBCA administration and late gadolinium enhancement (LGE) imaging to streamline workflow.

Materials and methods

Phantoms containing varying GBCA concentration (0–1.0 mM/L) were scanned with stimulated echo acquisition mode-based cDWI (STEAM-cDWI) with various heart rates (HRs) (30–200 beats/min) and second-order motion-compensated spin-echo-based cDWI (M2SE-cDWI) with various echo times (TEs) (75–500 ms). For patient study, 9 patients underwent STEAM-cDWI and 13 underwent M2SE-cDWI before and after GBCA administration. Contrast ratio (CR) and contrast-to-noise ratio (CNR) between the left ventricular myocardium and cavity, and ADC values were assessed.

Results

In phantoms, higher GBCA concentration, lower HR, and prolonged TE reduced SI. In STEAM-cDWI, CR and CNR significantly reduced after GBCA administration (CR of b = 400, 2.29 [1.80–5.46] vs. 1.15 [0.78–1.29], p = 0.0004; CNR of b = 400, 7.58 [4.82–11.1] vs. 0.57 [− 1.34 to 1.35], p = 0.0006; respectively); ADC values remained unchanged. In M2SE-cDWI, ADC values significantly decreased after GBCA administration (1.62 [1.15–1.97] vs. 1.26 [1.12– 1.51], × 10–3 mm2/s respectively, p = 0.004); only CR at b = 400 decreased significantly.

Discussion

cDWI is not recommended during the interval between GBCA administration and LGE imaging.