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Object <p>Development of a reproducible and long-term stable reference phantom for <sup>13</sup>C metabolic MRSI, addressing the need for accessible calibration and quality assurance tools across sites and platforms.</p> Materials and methods <p>The phantom was built from readily available labware (50&#xa0;mL centrifuge tubes, NMR glass vials) and 3D-printed holders, designed to ensure sufficient coil loading and excellent B<sub>0</sub> homogeneity. <sup>13</sup>C-labeled reference solutions were stabilized by argon degassing, sodium azide addition, and airtight flame sealing, with optional gadolinium doping to tune T<sub>1</sub>/T<sub>2</sub> relaxation. Performance was tested at 1.4&#xa0;T, 3&#xa0;T, and 11.7&#xa0;T using <sup>1</sup>H MRI, <sup>13</sup>C spectroscopy, and <sup>13</sup>C MRSI. </p> Results <p>The reference solutions remained chemically and spectrally stable for up to 20&#xa0;months under cooled, light-protected storage. Ethyl acetate provided a stable alternative to pyruvate, while gadolinium enabled the control of relaxation properties. Spectral assessment confirmed narrow linewidths, strong SNR, and reproducible peak separation across field strengths, validating the phantom’s suitability for calibration and method development. </p> Discussion <p>This low-cost, open-source design provides a durable and reproducible <sup>13</sup>C phantom that complements existing dynamic and metabolite-specific models. It enables long-term standardization, supports multi-center studies, and facilitates robust quality assurance in hyperpolarized and thermal <sup>13</sup>C MRSI. </p>

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Design and chemical composition of a reference phantom for 13C metabolic MRSI

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月12日

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  • Julian Schüle,
  • Christoph A. Müller,
  • Sebastian Lucas,
  • Leonard Schraff,
  • Stefan Menzel,
  • Tobias Speidel,
  • Ilai Schwartz,
  • Volker Rasche

摘要

Object

Development of a reproducible and long-term stable reference phantom for 13C metabolic MRSI, addressing the need for accessible calibration and quality assurance tools across sites and platforms.

Materials and methods

The phantom was built from readily available labware (50 mL centrifuge tubes, NMR glass vials) and 3D-printed holders, designed to ensure sufficient coil loading and excellent B0 homogeneity. 13C-labeled reference solutions were stabilized by argon degassing, sodium azide addition, and airtight flame sealing, with optional gadolinium doping to tune T1/T2 relaxation. Performance was tested at 1.4 T, 3 T, and 11.7 T using 1H MRI, 13C spectroscopy, and 13C MRSI.

Results

The reference solutions remained chemically and spectrally stable for up to 20 months under cooled, light-protected storage. Ethyl acetate provided a stable alternative to pyruvate, while gadolinium enabled the control of relaxation properties. Spectral assessment confirmed narrow linewidths, strong SNR, and reproducible peak separation across field strengths, validating the phantom’s suitability for calibration and method development.

Discussion

This low-cost, open-source design provides a durable and reproducible 13C phantom that complements existing dynamic and metabolite-specific models. It enables long-term standardization, supports multi-center studies, and facilitates robust quality assurance in hyperpolarized and thermal 13C MRSI.