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Objective <p>Liver regeneration after partial hepatectomy (PH) is markedly impaired in liver fibrosis, leading to serious complications. Non-invasive imaging methods for predicting regenerative capacity are crucial for preoperative planning and risk assessment. Gadobenate dimeglumine (Gd-BOPTA)-enhanced MRI at hepatobiliary phase has recently shown promise for assessing liver function. This study investigated the predictive value of Gd-BOPTA-enhanced MRI at hepatobiliary phase for liver regeneration in fibrotic rats.</p> Materials and methods <p>Thirty male Sprague–Dawley rats with experimentally induced liver fibrosis underwent Gd-BOPTA-enhanced MRI. The relative enhancement ratios of liver parenchyma (REL) and biliary system (REB) were quantified during the hepatobiliary phase. After 70% PH, the liver regeneration rate (LRR) was calculated on day 3 and 5. Stepwise multivariable linear regression was conducted to identify imaging and biochemical determinants of LRR.</p> Results <p>In fibrotic rats, the mean LRRs were 0.80 ± 0.10 (range, 0.64–1.01) and 1.06 ± 0.09 (range, 0.89–1.17) on day 3 and 5 after PH, respectively. Multivariable analysis identified REL (<i>p</i> = 0.002), REB (<i>p</i> = 0.026), and alanine aminotransferase (ALT; <i>p</i> = 0.040) as the strongest determinants of LRR on day 3 (Predicted LRR on day 3&#xa0;=&#xa0;0.368&#xa0;+&#xa0;1.332&#xa0;×&#xa0;REL&#xa0;+&#xa0;0.105&#xa0;×&#xa0;REB&#xa0;−&#xa0;0.001&#xa0;×&#xa0;ALT(IU/l)). On day 5, REL (<i>p</i> &lt; 0.001) and REB (<i>p</i> = 0.023) remained significant determinants of LRR (Predicted LRR on day 5&#xa0;=&#xa0;1.107&#xa0;+&#xa0;2.601&#xa0;×&#xa0;REL&#xa0;−&#xa0;0.173&#xa0;×&#xa0;REB).</p> Discussion <p>Gd-BOPTA-enhanced MRI at hepatobiliary phase can effectively predict LRR on day 3 and 5 after partial hepatectomy in fibrotic rats.</p>

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Gadobenate dimeglumine-enhanced MRI at hepatobiliary phase can predict liver regeneration after partial hepatectomy in fibrotic rats

  • 期刊论文

  • 发表日期：

    2026年1月20日

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  • Jiaying Bao,
  • Yuanyuan Li,
  • Gongzheng Wang,
  • Pengyu Zhang,
  • Jin Cui,
  • Suhong Duan,
  • Chengyong Qin,
  • Min Huang,
  • Xinya Zhao

摘要

Objective

Liver regeneration after partial hepatectomy (PH) is markedly impaired in liver fibrosis, leading to serious complications. Non-invasive imaging methods for predicting regenerative capacity are crucial for preoperative planning and risk assessment. Gadobenate dimeglumine (Gd-BOPTA)-enhanced MRI at hepatobiliary phase has recently shown promise for assessing liver function. This study investigated the predictive value of Gd-BOPTA-enhanced MRI at hepatobiliary phase for liver regeneration in fibrotic rats.

Materials and methods

Thirty male Sprague–Dawley rats with experimentally induced liver fibrosis underwent Gd-BOPTA-enhanced MRI. The relative enhancement ratios of liver parenchyma (REL) and biliary system (REB) were quantified during the hepatobiliary phase. After 70% PH, the liver regeneration rate (LRR) was calculated on day 3 and 5. Stepwise multivariable linear regression was conducted to identify imaging and biochemical determinants of LRR.

Results

In fibrotic rats, the mean LRRs were 0.80 ± 0.10 (range, 0.64–1.01) and 1.06 ± 0.09 (range, 0.89–1.17) on day 3 and 5 after PH, respectively. Multivariable analysis identified REL (p = 0.002), REB (p = 0.026), and alanine aminotransferase (ALT; p = 0.040) as the strongest determinants of LRR on day 3 (Predicted LRR on day 3 = 0.368 + 1.332 × REL + 0.105 × REB − 0.001 × ALT(IU/l)). On day 5, REL (p < 0.001) and REB (p = 0.023) remained significant determinants of LRR (Predicted LRR on day 5 = 1.107 + 2.601 × REL − 0.173 × REB).

Discussion

Gd-BOPTA-enhanced MRI at hepatobiliary phase can effectively predict LRR on day 3 and 5 after partial hepatectomy in fibrotic rats.