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Objective <p>To evaluate if co-registering Diffusion-Weighted Imaging (DWI) before generating Apparent Diffusion Coefficient (ADC) maps can improve differentiating benign and malignant breast lesions in MRI based on the A6702 thresholds.</p> Materials and methods <p>This IRB-approved study involved an in-house dataset and the publicly available ACRIN-6698 dataset, both including multi <i>b</i>-value DWI. In phase one, 16 ANTs library-based co-registration methods were evaluated on a subset of <i>n</i> = 138 cases from our in-house cohort. The quantitative assessment included mean ADC values of manually segmented lesions (diagnostic metrics using individual and A6702-defined thresholds) and coefficient of Variation. In the second phase, the best-performing methods were tested for generalizability on an unseen set of 40 cases (20 from in-house and 20 from external dataset). Three blinded readers segmented lesions on co-registered and non-co-registered ADC maps. Agreement and consistency were evaluated via Bland–Altman, segmentation distance, and intraclass correlation coefficient.</p> Results <p>Rigid co-registration using DWI at <i>b</i> = 750&#xa0;s/mm<sup>2</sup> as reference (b750-Rigid) improved accuracy of both optimal/conservative A6702 trial thresholds with sensitivity/specificity increasing from 93%/10% to 97%/30% and 100%/30% respectively. Mean ADC values were not significantly different after co-registration (<i>p</i> &gt; 0.05).</p> Discussion <p>Co-registration of DWI images before ADC map generation, particularly using b750-Rigid registration, seems promising for improving lesion classification in breast MRI. Further validation is warranted.</p>

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Influence of co-registration on lesion characterization in diffusion-weighted breast MRI

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月31日

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  • Luise Brock,
  • Andrzej Liebert,
  • Hannes Schreiter,
  • Dominika Skwierawska,
  • Chris Ehring,
  • Jessica Eberle,
  • Shirin Heidarikahkesh,
  • Frederik Bernd Laun,
  • Michael Uder,
  • Lorenz Kapsner,
  • Judith Lach,
  • Evelyn Wenkel,
  • Sabine Ohlmeyer,
  • Dominique Hadler,
  • Florian Knoll,
  • Sebastian Bickelhaupt

摘要

Objective

To evaluate if co-registering Diffusion-Weighted Imaging (DWI) before generating Apparent Diffusion Coefficient (ADC) maps can improve differentiating benign and malignant breast lesions in MRI based on the A6702 thresholds.

Materials and methods

This IRB-approved study involved an in-house dataset and the publicly available ACRIN-6698 dataset, both including multi b-value DWI. In phase one, 16 ANTs library-based co-registration methods were evaluated on a subset of n = 138 cases from our in-house cohort. The quantitative assessment included mean ADC values of manually segmented lesions (diagnostic metrics using individual and A6702-defined thresholds) and coefficient of Variation. In the second phase, the best-performing methods were tested for generalizability on an unseen set of 40 cases (20 from in-house and 20 from external dataset). Three blinded readers segmented lesions on co-registered and non-co-registered ADC maps. Agreement and consistency were evaluated via Bland–Altman, segmentation distance, and intraclass correlation coefficient.

Results

Rigid co-registration using DWI at b = 750 s/mm2 as reference (b750-Rigid) improved accuracy of both optimal/conservative A6702 trial thresholds with sensitivity/specificity increasing from 93%/10% to 97%/30% and 100%/30% respectively. Mean ADC values were not significantly different after co-registration (p > 0.05).

Discussion

Co-registration of DWI images before ADC map generation, particularly using b750-Rigid registration, seems promising for improving lesion classification in breast MRI. Further validation is warranted.