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Purpose <p>To reconstruct whole-heart images from free-running acquisitions through automated selection of data acceptance windows (ES: end-systole, MD: mid-diastole, ED: end-diastole) that account for heart rate variability (HRV).</p> Methods <p>SYMPHONIC was developed and validated in simulated (<i>N</i> = 1000) and volunteer (<i>N</i> = 14) data. To validate SYMPHONIC, the position of the detected acceptance windows, total duration, and resulting ventricular volume were compared to the simulated ground truth to establish metrics for temporal error, quiescent interval duration, and volumetric error, respectively. SYMPHONIC MD images and those using manually defined acceptance windows with fixed (MANUAL<sub>FIXED</sub>) or adaptive (MANUAL<sub>ADAPT</sub>) width were compared by measuring&#xa0;vessel sharpness (VS). The impact of HRV was assessed in patients (<i>N</i> = 6).</p> Results <p>Mean temporal error was larger for MD than for ED and ED in both simulations and volunteers. Mean volumetric errors were comparable. Interval duration differed for ES (<i>p</i> = 0.04) and ED (<i>p</i> &lt; 10<sup>–3</sup>), but not for MD (<i>p</i> = 0.08). In simulations, SYMPHONIC and MANUAL<sub>ADAPT</sub> provided consistent VS for increasing HRV, while VS decreased for MANUAL<sub>FIXED</sub>. In volunteers, VS differed between MANUAL<sub>ADAPT</sub> and MANUAL<sub>FIXED</sub> (<i>p</i> &lt; 0.01), but not between SYMPHONIC and MANUAL<sub>ADAPT</sub> (<i>p</i> = 0.03) or MANUAL<sub>FIXED</sub> (<i>p</i> = 0.42).</p> Conclusion <p>SYMPHONIC accurately detected quiescent cardiac phases in free-running data and resulted in high-quality whole-heart images despite the presence of HRV.</p>

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Automated adaptive detection and reconstruction of quiescent cardiac phases in free-running whole-heart acquisitions using Synchronicity Maps from PHysiological mOtioN In Cine (SYMPHONIC) MRI

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  • 发表日期：

    2025年8月19日

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  • Giulia M. C. Rossi Bongiolatti,
  • Nemanja Masala,
  • Jessica A. M. Bastiaansen,
  • Jérôme Yerly,
  • Milan Prša,
  • Tobias Rutz,
  • Estelle Tenisch,
  • Salim Si-Mohamed,
  • Matthias Stuber,
  • Christopher W. Roy

摘要

Purpose

To reconstruct whole-heart images from free-running acquisitions through automated selection of data acceptance windows (ES: end-systole, MD: mid-diastole, ED: end-diastole) that account for heart rate variability (HRV).

Methods

SYMPHONIC was developed and validated in simulated (N = 1000) and volunteer (N = 14) data. To validate SYMPHONIC, the position of the detected acceptance windows, total duration, and resulting ventricular volume were compared to the simulated ground truth to establish metrics for temporal error, quiescent interval duration, and volumetric error, respectively. SYMPHONIC MD images and those using manually defined acceptance windows with fixed (MANUALFIXED) or adaptive (MANUALADAPT) width were compared by measuring vessel sharpness (VS). The impact of HRV was assessed in patients (N = 6).

Results

Mean temporal error was larger for MD than for ED and ED in both simulations and volunteers. Mean volumetric errors were comparable. Interval duration differed for ES (p = 0.04) and ED (p < 10–3), but not for MD (p = 0.08). In simulations, SYMPHONIC and MANUALADAPT provided consistent VS for increasing HRV, while VS decreased for MANUALFIXED. In volunteers, VS differed between MANUALADAPT and MANUALFIXED (p < 0.01), but not between SYMPHONIC and MANUALADAPT (p = 0.03) or MANUALFIXED (p = 0.42).

Conclusion

SYMPHONIC accurately detected quiescent cardiac phases in free-running data and resulted in high-quality whole-heart images despite the presence of HRV.