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<p>Quantitative MRI has been an active area of research for decades and has produced a huge range of approaches with enormous potential for patient benefit. In many cases, however, there are challenges with reproducibility which have hampered clinical translation. Quantitative MRI is a form of measurement and like any other form of measurement it requires a supporting metrological framework to be fully consistent and compatible with the international system of units. This means not just expressing results in terms of seconds, meters, etc., but demonstrating consistency to their internationally recognized definitions. Such a framework&#xa0;for MRI is not yet complete, but a considerable amount of work has been done internationally towards building one. This article describes the current state of the art for MRI metrology, including a detailed description of metrological principles and how they are relevant to fully quantitative MRI. It also undertakes a gap analysis of where we are versus where we need to be to support reproducibility in MRI. It focusses particularly on the role and activities of national measurement institutes across the globe, illustrating the genuinely international and collaborative nature of the field.</p>

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Metrology for MRI: the field you’ve never heard of

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月19日

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  • Matt G. Hall,
  • Matt Cashmore,
  • Hyo-Min Cho,
  • Bernd Ittermann,
  • Kathryn E. Keenan,
  • Christoph Kolbitsch,
  • Changwoo Lee,
  • Chengwei Li,
  • Asante Ntata,
  • Katie Obee,
  • Zhang Pu,
  • Stephen E. Russek,
  • Karl F. Stupic,
  • Lukas Winter,
  • Luca Zilberti,
  • Michael Steckner

摘要

Quantitative MRI has been an active area of research for decades and has produced a huge range of approaches with enormous potential for patient benefit. In many cases, however, there are challenges with reproducibility which have hampered clinical translation. Quantitative MRI is a form of measurement and like any other form of measurement it requires a supporting metrological framework to be fully consistent and compatible with the international system of units. This means not just expressing results in terms of seconds, meters, etc., but demonstrating consistency to their internationally recognized definitions. Such a framework for MRI is not yet complete, but a considerable amount of work has been done internationally towards building one. This article describes the current state of the art for MRI metrology, including a detailed description of metrological principles and how they are relevant to fully quantitative MRI. It also undertakes a gap analysis of where we are versus where we need to be to support reproducibility in MRI. It focusses particularly on the role and activities of national measurement institutes across the globe, illustrating the genuinely international and collaborative nature of the field.