<p>Sweet potato foot rot, first confirmed in Okinawa in 2018, is spreading to southern Kyushu and causing serious yield losses. A previous study showed that integrating soil treatment with trifloxystrobin wettable powder, seedling treatment with benomyl wettable powder, and foliar sprays with fluazinam and triflumizole wettable powders and basic copper sulfate is highly effective. Here we evaluated the efficacy of this integrated system and effects on yields using two new varieties resistant to foot rot and the main variety Chura-Koi-Beni in Okinawa. We evaluated three trifloxystrobin systems: system 1 (described above), a reduced-spray version of system 1 (system 2), and system 2 with copper sulfate applications (system 3). Disease incidence on Chura-Koi-Beni was lower in all three systems than in the conventional system, and yields were statistically similar to or greater than in the conventional. The new varieties also showed low levels of aboveground symptoms, indicating that combining them with the trifloxystrobin systems can further enhance disease suppression. Overall, the three trifloxystrobin-based systems in Okinawa Prefecture were effective against this disease; even the reduced spray (system 2) can be effective, and system 3 has the potential to achieve control equal to or greater than with system 2. In addition, combining resistant varieties can provide even better disease control.</p>