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<p>The presence of natural and synthetic toxic compounds in the environment requires the development of advanced detection methods. Here we review proteomics technologies for toxicity screening, with focus on principles, current status, mass spectrometry-based proteomics, protein microarray, and in-frame tagging method. Concerning&#xa0;mass spectrometry-based proteomics, we detail liquid chromatography-tandem mass spectrometry, label-free quantification, and thermal proteome profiling. We discuss the integration of the latest advances in proteomics technologies, such as single-cell proteomics, data-independent acquisition, and multi-omics approaches.</p>

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Proteomics technologies in toxicity screening: a review

  • 期刊论文

  • 发表日期：

    2025年1月3日

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  • Yushi Jin,
  • Zhejia Sun,
  • April Z. Gu,
  • Xiaohong Zhou

摘要

The presence of natural and synthetic toxic compounds in the environment requires the development of advanced detection methods. Here we review proteomics technologies for toxicity screening, with focus on principles, current status, mass spectrometry-based proteomics, protein microarray, and in-frame tagging method. Concerning mass spectrometry-based proteomics, we detail liquid chromatography-tandem mass spectrometry, label-free quantification, and thermal proteome profiling. We discuss the integration of the latest advances in proteomics technologies, such as single-cell proteomics, data-independent acquisition, and multi-omics approaches.