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<p>Epilepsy is one of the most common chronic neurological diseases in adolescents. The hormonal changes often lead to alterations in clinical presentation (including associated comorbidities) in childhood-onset epilepsies, and also the manifestation of a&#xa0;variety of new syndromes over time, while age-dependent syndromes may spontaneously go into permanent remission. Gender-specific hormonal changes influence the pharmacodynamic and pharmacokinetic profiles of antiseizure medications (ASM) and thus their range of effects and side effects. Finally, the specific psychosocial aspects of this age group have to be considered, and special programs to support coping strategies, personal responsibility and adherence to treatment have to be offered. This review highlights particularities of ASM treatment for adolescents with epilepsy. Differences to the recently published guidelines for adults are discussed.</p>

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Specific characteristics of pharmacotherapy and management in adolescents with epilepsy. English version

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月11日

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  • M. Feucht,
  • B. Pimpel

摘要

Epilepsy is one of the most common chronic neurological diseases in adolescents. The hormonal changes often lead to alterations in clinical presentation (including associated comorbidities) in childhood-onset epilepsies, and also the manifestation of a variety of new syndromes over time, while age-dependent syndromes may spontaneously go into permanent remission. Gender-specific hormonal changes influence the pharmacodynamic and pharmacokinetic profiles of antiseizure medications (ASM) and thus their range of effects and side effects. Finally, the specific psychosocial aspects of this age group have to be considered, and special programs to support coping strategies, personal responsibility and adherence to treatment have to be offered. This review highlights particularities of ASM treatment for adolescents with epilepsy. Differences to the recently published guidelines for adults are discussed.