Scholarlink

<p>Antiseizure medications (ASM) are usually taken over a long period of time in adults. Depending on the pharmacokinetic profile, various accompanying effects on the organism and on the efficacy and tolerability of other medications are possible that can also lead to typical alterations in laboratory results. Therefore, in relation to this it is crucial to identify such risk factors by appropriate laboratory diagnostics prior to the initiation of a selected ASM that can possibly lead to health-threatening changes during treatment and under certain circumstances can influence the choice of a&#xa0;given ASM before initiating treatment. This update review should help to become acquainted with such constellations and to give advice on which parameters should be determined and when. A&#xa0;second important component of the epileptological laboratory diagnostics is related to ASM serum levels. The general role of serum levels including the so-called therapeutic range was previously overestimated. It is now known that ASM serum concentrations should be determined only under appropriate clinical circumstances and certainly not routinely. We now prefer the definition of an individual and not a&#xa0;general reference range. Based on the latest data on recently introduced ASMs we even propose to call this range typical or to be expected without undertaking immediate clinical steps without corresponding clinical symptoms.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Pharmacotherapy and accompanying laboratory diagnostics in adulthood. English version

  • 期刊论文

  • 发表日期：

    2025年5月27日

查看全文
  • Bernhard J. Steinhoff

摘要

Antiseizure medications (ASM) are usually taken over a long period of time in adults. Depending on the pharmacokinetic profile, various accompanying effects on the organism and on the efficacy and tolerability of other medications are possible that can also lead to typical alterations in laboratory results. Therefore, in relation to this it is crucial to identify such risk factors by appropriate laboratory diagnostics prior to the initiation of a selected ASM that can possibly lead to health-threatening changes during treatment and under certain circumstances can influence the choice of a given ASM before initiating treatment. This update review should help to become acquainted with such constellations and to give advice on which parameters should be determined and when. A second important component of the epileptological laboratory diagnostics is related to ASM serum levels. The general role of serum levels including the so-called therapeutic range was previously overestimated. It is now known that ASM serum concentrations should be determined only under appropriate clinical circumstances and certainly not routinely. We now prefer the definition of an individual and not a general reference range. Based on the latest data on recently introduced ASMs we even propose to call this range typical or to be expected without undertaking immediate clinical steps without corresponding clinical symptoms.