Unusual and unexpected positive spontaneous courses of chronic drug-resistant epilepsies in adults

In general, the prognosis of epilepsy in adults with a drug-resistant course for many years is poor if epilepsy surgery is not considered as a curative procedure. We tend to understand unusual positive courses to be a result of the therapeutic interventions, which may be the case but remains unproven. The aim of this article is to emphasize that the importance of therapeutic strategies should not be overemphasized by reporting three cases of patients who have been followed and advised by myself for decades, have almost never benefitted from my therapeutic interventions, have suffered from highly active and drug-resistant epilepsies, and, finally, who became and remained seizure free without any apparently beneficial supportive therapeutic action.