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Objective <p>This meta-analysis evaluates the effectiveness and safety of ramicotomy versus sympathetic chain interruption (SCI) in treating primary hyperhidrosis (PH).</p> Methods <p>A comprehensive literature search was conducted across multiple databases, including PubMed, Embase, Web of Science, Ovid, Cochrane Library, CNKI, and Wanfang, covering studies from their inception through October 2024. A total of 10 studies involving 970 patients were included, with 504 patients undergoing ramicotomy and 466 receiving SCI.</p> Results <p>The analysis revealed that patients undergoing ramicotomy experienced significantly lower rates of compensatory hyperhidrosis (CH) [odds ratio (OR) 0.41, 95% confidence interval (CI) 0.20–0.85, <i>P</i> = 0.02], severe CH (OR 0.17, 95% CI 0.06, 0.47, <i>P</i> &lt; 0.001), and postoperative hand dryness (OR 0.10, 95% CI 0.01–0.72, <i>P</i> = 0.02), along with a higher recurrence rate (OR 4.03, 95% CI 2.38, 6.85, <i>P</i> &lt; 0.001). No significant differences were observed in operative duration [mean difference (MD) = 0.19, 95% CI −18.23, 18.60, <i>P</i> = 0.98 &gt; 0.05], length of hospital stay (MD = −0.08, 95% CI −0.19, 0.04, <i>P</i> = 0.20 &gt; 0.05), total postoperative complications (OR 0.41, 95% CI 0.07, 2.34, <i>P</i> = 0.32 &gt; 0.05), or surgical satisfaction (OR 0.93, 95% CI 0.45, 1.91, <i>P</i> = 0.83 &gt; 0.05).</p> Conclusions <p>While ramicotomy results in lower incidences of CH and postoperative hand dryness, its higher recurrence rate suggests that its application should be cautious to manage PH effectively.</p>

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Comparison of the effectiveness and safety between ramicotomy and sympathetic chain interruption in the treatment of primary hyperhidrosis: a meta-analysis

  • 期刊论文

  • 发表日期：

    2025年2月5日

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  • Sheng Yong,
  • Xiaotong Yang,
  • Wei Cao,
  • Weirun Min,
  • Yunjiu Gou

摘要

Objective

This meta-analysis evaluates the effectiveness and safety of ramicotomy versus sympathetic chain interruption (SCI) in treating primary hyperhidrosis (PH).

Methods

A comprehensive literature search was conducted across multiple databases, including PubMed, Embase, Web of Science, Ovid, Cochrane Library, CNKI, and Wanfang, covering studies from their inception through October 2024. A total of 10 studies involving 970 patients were included, with 504 patients undergoing ramicotomy and 466 receiving SCI.

Results

The analysis revealed that patients undergoing ramicotomy experienced significantly lower rates of compensatory hyperhidrosis (CH) [odds ratio (OR) 0.41, 95% confidence interval (CI) 0.20–0.85, P = 0.02], severe CH (OR 0.17, 95% CI 0.06, 0.47, P < 0.001), and postoperative hand dryness (OR 0.10, 95% CI 0.01–0.72, P = 0.02), along with a higher recurrence rate (OR 4.03, 95% CI 2.38, 6.85, P < 0.001). No significant differences were observed in operative duration [mean difference (MD) = 0.19, 95% CI −18.23, 18.60, P = 0.98 > 0.05], length of hospital stay (MD = −0.08, 95% CI −0.19, 0.04, P = 0.20 > 0.05), total postoperative complications (OR 0.41, 95% CI 0.07, 2.34, P = 0.32 > 0.05), or surgical satisfaction (OR 0.93, 95% CI 0.45, 1.91, P = 0.83 > 0.05).

Conclusions

While ramicotomy results in lower incidences of CH and postoperative hand dryness, its higher recurrence rate suggests that its application should be cautious to manage PH effectively.