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<p>We investigated a maxillary bone defect model to test a synthetic extracellular matrix (HyStem®-HP) (hyaluronan) alone or associated with BG-Carb (BG-Carb)—a bioactive glass-carbon material made of a green waste (<i>Equisetum hyemale</i>). BG-Carb cytocompatibility was evaluated in Dental Pulp Cells (DPC) at 24, 48, and 72&#xa0;h. Animals were treated with both materials and euthanized on days 7 and 21. The inflammatory process, bone regeneration, and epithelial formation were quantified. Data were analyzed at a 95% confidence level using Student’s<i> t</i>-test or Mann Whitney test (<i>p</i> &lt; 0.05). BG-Carb did not impair dental pulp cell viability. BG-Carb also promoted increased bone formation at 7&#xa0;days compared to HyStem®-HP alone. At 21&#xa0;days, bone formation was similar between groups; however, less granulation tissue and greater epithelial thickness were observed in the BG-Carb-treated samples. BG-Carb showed biocompatibility promoting early bone regeneration and tissue organization during repair. BG-Carb is a promise candidate for bone regeneration.</p>

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Equisetum hyemale enhances local bone regeneration in murine maxillary defects: an in vivo study

  • 期刊论文

  • 发表日期：

    2025年11月10日

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  • Daniel Marques Leão,
  • Natália Aparecida Gomes,
  • Rosangela Maria Ferreira Costa e Silva,
  • Gleide Fernandes Avelar,
  • Isabella Bittencourt do Valle,
  • Frederico Santos Lages,
  • Ivana Márcia Alves Diniz

摘要

We investigated a maxillary bone defect model to test a synthetic extracellular matrix (HyStem®-HP) (hyaluronan) alone or associated with BG-Carb (BG-Carb)—a bioactive glass-carbon material made of a green waste (Equisetum hyemale). BG-Carb cytocompatibility was evaluated in Dental Pulp Cells (DPC) at 24, 48, and 72 h. Animals were treated with both materials and euthanized on days 7 and 21. The inflammatory process, bone regeneration, and epithelial formation were quantified. Data were analyzed at a 95% confidence level using Student’s t-test or Mann Whitney test (p < 0.05). BG-Carb did not impair dental pulp cell viability. BG-Carb also promoted increased bone formation at 7 days compared to HyStem®-HP alone. At 21 days, bone formation was similar between groups; however, less granulation tissue and greater epithelial thickness were observed in the BG-Carb-treated samples. BG-Carb showed biocompatibility promoting early bone regeneration and tissue organization during repair. BG-Carb is a promise candidate for bone regeneration.