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<p>This study aimed to evaluate the efficacy of gadolinium-doped hydroxyapatite nanoparticles (Gd–HA Nps) as coating for orthodontic miniscrews. Gd–HA Nps were synthesized by sol-gel method and coated on titanium miniscrews utilizing dip coating. The coated screws were analyzed using Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), and Energy dispersive X-ray spectroscopy (EDS), confirming the effective application of the coating and the presence of 1.36 % Gd by weight. The antimicrobial effectiveness was evaluated using agar diffusion assays against <i>Staphylococcus aureus (S. aureus) (p=0.029), Streptococcus mutans (S. mutans) (p=0.03)</i>, and <i>Enterococcus faecalis (E. faecalis) (p=0.028)</i>. Gd–HA coated screws exhibited significantly larger zones of inhibition in comparison to pure HA-coated screws. The study indicates that Gd–HA coatings improve antibacterial capabilities, presenting a viable approach to mitigate peri-implant infections and failures.</p>

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Gadolinium-doped hydroxyapatite coating on orthodontic miniscrews— an in-vitro analysis

  • 期刊论文

  • 发表日期：

    2025年6月5日

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  • Priyadharshni Ramachandran,
  • Shweta Nagesh,
  • S. P. Mani,
  • Revathi Peddu,
  • Boyapati Ramanarayana

摘要

This study aimed to evaluate the efficacy of gadolinium-doped hydroxyapatite nanoparticles (Gd–HA Nps) as coating for orthodontic miniscrews. Gd–HA Nps were synthesized by sol-gel method and coated on titanium miniscrews utilizing dip coating. The coated screws were analyzed using Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), and Energy dispersive X-ray spectroscopy (EDS), confirming the effective application of the coating and the presence of 1.36 % Gd by weight. The antimicrobial effectiveness was evaluated using agar diffusion assays against Staphylococcus aureus (S. aureus) (p=0.029), Streptococcus mutans (S. mutans) (p=0.03), and Enterococcus faecalis (E. faecalis) (p=0.028). Gd–HA coated screws exhibited significantly larger zones of inhibition in comparison to pure HA-coated screws. The study indicates that Gd–HA coatings improve antibacterial capabilities, presenting a viable approach to mitigate peri-implant infections and failures.