Curcumin administration mitigates periodontitis-induced tissue damage in hypercholesterolemic rats: a natural preventive approach

This study investigated the preventive effect of curcumin (CUR) on tooth-supporting structures in hypercholesterolemic (HC) rats with periodontitis (P). Wistar rats (8 weeks old) (n = 30) were assigned to six groups based on dietary intake, CUR–piperine combination treatment and P induction. P was induced in four groups using a ligature model. Serum lipid profiles, oxidative stress parameters, radiographic, histological and histomorphometric analyses were performed. HC rats showed elevated serum cholesterol levels (p < 0.001). Moreover, topical administration of CUR did not regulate hypercholesterolemia in this model. The HC diet increased oxidative stress in gingival tissue, exacerbated by P, whereas CUR attenuated reactive species generation (p < 0.001) and reduced catalase (CAT) activity, possibly due to its antioxidant properties. Histological analysis revealed extensive erosive surfaces and osteoclast presence in the P groups, with the HC + P group showing the highest rate of bone resorption. The CUR-treated groups showed less bone resorption and more bone formation, indicating a protective effect. Histomorphometric studies showed a significant increase in bone volume in the CUR groups compared to the P groups (p < 0.001). CUR prevented bone resorption induced by P and HC diet, with larger osteoblastic surfaces and fewer osteoclasts, suggesting inhibition of bone resorption. CUR also prevented collagen fiber destruction caused by the HC diet. Overall, the study suggests a potential therapeutic role for CUR in mitigating periodontal tissue damage associated with hypercholesterolemia and P, due to its antioxidant and anti-inflammatory properties. Further research would be needed to validate its clinical efficacy as an adjunctive treatment for P.