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<p>STAT1, a key mediator of cellular responses to interferons and cytokines, has not been comprehensively analyzed in pan-cancer studies regarding its role in tumor biology. This study investigated STAT1 expression, its prognostic value, and its correlation with immune status in various types of cancer. We analyzed STAT1 expression, methylation, genomic alterations, survival, immune cell infiltration, and functional pathways using the TCGA, GTEx, GEO, TIMER, CCLE, and The Human Protein Atlas (HPA) databases. STAT1 expression was significantly higher in tumor tissues than in normal tissues and correlated with poorer overall survival. It was associated with the infiltration of B cells, CD4 + T cells, CD8 + T cells, neutrophils, macrophages, and dendritic cells. Enrichment analysis linked STAT1 to cancer-related pathways, cytokine-receptor interactions, and toll-like receptor signaling. Elevated STAT1 expression is associated with poor prognosis and immune infiltration, suggesting its potential as a biomarker and therapeutic target for cancer.</p>

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Signal Transduction and Transcription Activator 1 in Pan-Cancer: Prognostic and Immunological Value

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月29日

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  • Ying Wang,
  • Yongguang Zhang,
  • Fengmei Wang,
  • Longguan Tang,
  • Xun Xiao,
  • Hu Zhao,
  • Qingsong Sheng

摘要

STAT1, a key mediator of cellular responses to interferons and cytokines, has not been comprehensively analyzed in pan-cancer studies regarding its role in tumor biology. This study investigated STAT1 expression, its prognostic value, and its correlation with immune status in various types of cancer. We analyzed STAT1 expression, methylation, genomic alterations, survival, immune cell infiltration, and functional pathways using the TCGA, GTEx, GEO, TIMER, CCLE, and The Human Protein Atlas (HPA) databases. STAT1 expression was significantly higher in tumor tissues than in normal tissues and correlated with poorer overall survival. It was associated with the infiltration of B cells, CD4 + T cells, CD8 + T cells, neutrophils, macrophages, and dendritic cells. Enrichment analysis linked STAT1 to cancer-related pathways, cytokine-receptor interactions, and toll-like receptor signaling. Elevated STAT1 expression is associated with poor prognosis and immune infiltration, suggesting its potential as a biomarker and therapeutic target for cancer.