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<p>The skin, as the body’s largest organ, relies on complex molecular networks to maintain homeostasis and repair damage. Recent advances in genomic research have highlighted the significance of long non-coding RNAs (lncRNAs), transcripts longer than 200 nucleotides, which act as key regulators of gene expression rather than mere transcriptional byproducts. Growing evidence suggests that lncRNAs influence critical signaling pathways, including <i>PI3K/AKT/mTOR, Wnt/β-catenin, NF-κB, JAK/STAT</i>, and <i>TGF-β/SMAD</i> shaping both normal skin biology and disease processes. This review synthesizes current knowledge on how to regulate the pathogenesis of dermatological conditions, including atopic dermatitis, psoriasis, vitiligo, systemic sclerosis, melanoma, and others. By outlining their potential roles as biomarkers and therapeutic targets, this work underscores the novelty and clinical relevance of lncRNA research in dermatology.</p>

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A symphony of signals: the intricate role of lncRNAs in dermatological disorders

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月18日

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  • Ahmad Ghorbani Vanan,
  • Samaneh Nouri,
  • Farnaz Hassanzadeh,
  • Milad Taghizadeh-Anvar,
  • Mehdi Heidari Naeij,
  • Aida Varghaei,
  • Safa Tahmasebi

摘要

The skin, as the body’s largest organ, relies on complex molecular networks to maintain homeostasis and repair damage. Recent advances in genomic research have highlighted the significance of long non-coding RNAs (lncRNAs), transcripts longer than 200 nucleotides, which act as key regulators of gene expression rather than mere transcriptional byproducts. Growing evidence suggests that lncRNAs influence critical signaling pathways, including PI3K/AKT/mTOR, Wnt/β-catenin, NF-κB, JAK/STAT, and TGF-β/SMAD shaping both normal skin biology and disease processes. This review synthesizes current knowledge on how to regulate the pathogenesis of dermatological conditions, including atopic dermatitis, psoriasis, vitiligo, systemic sclerosis, melanoma, and others. By outlining their potential roles as biomarkers and therapeutic targets, this work underscores the novelty and clinical relevance of lncRNA research in dermatology.