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<p>Lung cancer (LC) remains the leading cause of cancer-related deaths globally. Liquid biopsy offers an accurate and non-invasive screening approach for early detection of LC overcoming the limitations of the current recommended low-dose computed tomography (LDCT). In the current review, we summarized the latest advancements in liquid biopsy for LC screening, evaluating the biological relevance, predictive accuracy, and detection techniques associated with various biomarkers including circulating tumor DNA, proteins, and metabolites. We also addressed the unresolved questions of how to integrate liquid biopsy into routine clinical practice to improve LC outcomes by cost-effective analysis. It is hoped that this study can shed light upon the future development of LC screening methods and provide insights for the potential integration of liquid biopsy into the current clinical practice.</p>

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Liquid biopsy in lung cancer screening: rationale, progress, opportunities and challenges

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月18日

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  • Caizheng Li,
  • Hongtao Jiang,
  • Xiaoran Sun,
  • Fanqi Meng,
  • Peng Cui,
  • Guoqiang Wang,
  • Chang Liu,
  • Shangli Cai,
  • Feidie Duan,
  • Qiaoli Su,
  • Can Zhao

摘要

Lung cancer (LC) remains the leading cause of cancer-related deaths globally. Liquid biopsy offers an accurate and non-invasive screening approach for early detection of LC overcoming the limitations of the current recommended low-dose computed tomography (LDCT). In the current review, we summarized the latest advancements in liquid biopsy for LC screening, evaluating the biological relevance, predictive accuracy, and detection techniques associated with various biomarkers including circulating tumor DNA, proteins, and metabolites. We also addressed the unresolved questions of how to integrate liquid biopsy into routine clinical practice to improve LC outcomes by cost-effective analysis. It is hoped that this study can shed light upon the future development of LC screening methods and provide insights for the potential integration of liquid biopsy into the current clinical practice.