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<p>The detection of platelet-specific antibodies plays an important role&#xa0; in the clinical&#xa0;diagnosis of primary immune thrombocytopenia (ITP). MAIPA assay and PakAuto assay are the two main methods for this purpose. However, a comprehensive comparative evaluation of these techniques in clinical practice remains lacking. In this study, we collected 48 patients with thrombocytopenia. MAIPA and PakAuto are used to examine platelet-specific &#xa0;antibodies&#xa0;synchronously. Based on methodologies and analysis of experimental results, we conclude that PakAuto assay with a high sensitivity and accuracy can offer higher throughput and broader human platelet antibodies detection capabilities, making it more suitable for screening. </p>

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Comparative analysis of MAIPA assay and PakAuto assay for the diagnosis of primary immune thrombocytopenia

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月7日

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  • Lixuan Chen,
  • Chaolin Chen,
  • Rui Tuo,
  • Limei Ye,
  • Shuting Ouyang,
  • Hao Su,
  • Jianxi Lai,
  • Ying Feng,
  • Yang Xiao

摘要

The detection of platelet-specific antibodies plays an important role  in the clinical diagnosis of primary immune thrombocytopenia (ITP). MAIPA assay and PakAuto assay are the two main methods for this purpose. However, a comprehensive comparative evaluation of these techniques in clinical practice remains lacking. In this study, we collected 48 patients with thrombocytopenia. MAIPA and PakAuto are used to examine platelet-specific  antibodies synchronously. Based on methodologies and analysis of experimental results, we conclude that PakAuto assay with a high sensitivity and accuracy can offer higher throughput and broader human platelet antibodies detection capabilities, making it more suitable for screening.